CPLM-023500

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-023500

UniProt Accession

SPIT2_MOUSE; Q9WU03; Q5D0F2; Q9WU04; Q9WU05

Genbank Protein ID

AF099016; AF099019; AF099020; BC003431; BC026419

Genbank Nucleotide ID

AAD22172.1; AAD22173.1; AAD22174.1; AAH03431.1; AAH26419.1

Protein Name

Kunitz-type protease inhibitor 2

Protein Synonyms/Alias

Hepatocyte growth factor activator inhibitor type 2; HAI-2

Gene Name

Spint2

Gene Synonyms/Alias

Hai2

Created Date

July 27, 2013

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Lysine Modification

Position	Peptide	Type	References
242	VWSTADDKEQLVKNT	ubiquitination	[1]
247	DDKEQLVKNTCVL**	ubiquitination	[1]

Reference

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

Inhibitor of HGF activator.

Sequence Annotation

DOMAIN 38 88 BPTI/Kunitz inhibitor 1.
DOMAIN 133 183 BPTI/Kunitz inhibitor 2.
CARBOHYD 57 57 N-linked (GlcNAc...) (Potential).
CARBOHYD 94 94 N-linked (GlcNAc...) (Potential).
DISULFID 38 88 By similarity.
DISULFID 47 71 By similarity.
DISULFID 63 84 By similarity.
DISULFID 133 183 By similarity.
DISULFID 142 166 By similarity.
DISULFID 158 179 By similarity.

Keyword

Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Protease inhibitor; Reference proteome; Repeat; Serine protease inhibitor; Signal; Transmembrane; Transmembrane helix.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

252 AA

Protein Sequence

MAQLCELRRG RALLALVASL LLSGAQVASR ELDVHESCGV SKVVGKCRAS IPRWWYNITD 60
GSCQPFVYGG CEGNGNNYQS KEECLDKCAG VTENTTDDMA RNRNGADSSV LSVPRKQSAE 120
DLSAEIFNYE EYCVPKAVTG PCRAAFPRWY YDTEKNSCIS FIYGGCRGNK NSYLSQEACM 180
QHCSGKQMHP FLTPGLKAVI LVGLFLMVLI LLLGTSMVCL IRVVRRKQER ALRTVWSTAD 240
DKEQLVKNTC VL 252

Gene Ontology

GO:0005737; C:cytoplasm; IEA:Compara.
GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.

Interpro

IPR002223; Prot_inh_Kunz-m.
IPR020901; Prtase_inh_Kunz-CS.

Pfam

PF00014; Kunitz_BPTI

SMART

SM00131; KU

PROSITE

PS00280; BPTI_KUNITZ_1
PS50279; BPTI_KUNITZ_2

PRINTS