CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044774
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Max-like protein X 
Protein Synonyms/Alias
  
Gene Name
 MLX 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
140DFSIGSQKLSKAIVLubiquitination[1, 2]
143IGSQKLSKAIVLQKTubiquitination[2, 3]
149SKAIVLQKTIDYIQFubiquitination[2]
162QFLHKEKKKQEEEVSubiquitination[2]
163FLHKEKKKQEEEVSTubiquitination[2]
182VTALKIMKVNYEQIVubiquitination[2]
190VNYEQIVKAHQDNPHubiquitination[1, 4]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 248 AA 
Protein Sequence
MTEPGASPED PWVKASPVGA HAGEGRAGRA RARRGAGRRG ASLLSPKSPT LSVPRGCRED 60
SSHPACAKVE YAYSDNSLDP DDEDSDYHQE AYKESYKDRR RRAHTQAEQK RRDAIKRGYD 120
DLQTIVPTCQ QQDFSIGSQK LSKAIVLQKT IDYIQFLHKE KKKQEEEVST LRKDVTALKI 180
MKVNYEQIVK AHQDNPHEGE DQVSDQVKFN VFQGIMDSLF QSFNASISVA SFQELSACVF 240
SWIEEHCK 248 
Gene Ontology
  
Interpro
 IPR011598; bHLH_dom. 
Pfam
 PF00010; HLH 
SMART
 SM00353; HLH 
PROSITE
 PS50888; BHLH 
PRINTS