CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011465
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Alcohol-sensitive RING finger protein 1 
Protein Synonyms/Alias
  
Gene Name
 ASR1 
Gene Synonyms/Alias
 YPR093C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
117TLVMDTIKIIQCSICubiquitination[1]
261LYRLSDNKYLPDQYDubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, VillĂ©n J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301
Functional Description
 Required for tolerance to alcohol. 
Sequence Annotation
 ZN_FING 4 48 RING-type 1; atypical.
 ZN_FING 121 168 RING-type 2; degenerate.  
Keyword
 Complete proteome; Cytoplasm; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 288 AA 
Protein Sequence
MEECPICLAD DQEGEQFGCL NVCGHKFHLN CIREWHKYSI NLKCPICRVE STHLEVGEGQ 60
HALSINLKMG FMIKNAIDYV GAETTNERNE DDTGEQDQEI EFLSERLRGT LVMDTIKIIQ 120
CSICGDTDVS RLSLYCQDCE AIYHETCLRG LACEVGDRNT WQECTDCRSN ALLELRMGAI 180
SSQLASYDSR NSMIFAGELR DKHSVKTQQM YEQIRNAKHK IQMHVRRALD RYPLPLLRFK 240
DAYKHVNKQV SRKLYRLSDN KYLPDQYDYD SLARTGVHTE LLIYCHDE 288 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0004842; F:ubiquitin-protein ligase activity; IDA:SGD.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0045471; P:response to ethanol; IMP:SGD. 
Interpro
 IPR019786; Zinc_finger_PHD-type_CS.
 IPR001965; Znf_PHD.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF13639; zf-RING_2 
SMART
 SM00249; PHD
 SM00184; RING 
PROSITE
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS