CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038169
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Sptbn4 
Protein Synonyms/Alias
  
Gene Name
 Sptbn4 
Gene Synonyms/Alias
 Spnb4 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
132DKALQFLKEQRVHLEacetylation[1]
132DKALQFLKEQRVHLEubiquitination[2]
235VDLSKLTKSNANYNLubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2561 AA 
Protein Sequence
MAQVPGEVDN MEGPAVSNNN NPSARWESPD RGWDREPPAA ANAAASLFEC SRIKALADER 60
EAVQKKTFTK WVNSHLARVG CHIGDLYADL RDGFVLTRLL EVLSGEQLPR PTRGRMRIHS 120
LENVDKALQF LKEQRVHLEN VGSHDIVDGN HRLTLGLVWT IILRFQIQVI KIETEDNRET 180
RSAKDALLLW CQMKTAGYPE VNIQNFTTSW RDGLAFNALI HRHRPDLVDL SKLTKSNANY 240
NLQRAFRTAE QHLGLARLLD PEDVNMEAPD EKSIITYVVS FYHYFSKMKA LAVEGKRIGK 300
VLDQVLEVDK IIERYEELAA ELLAWIHRTV DLISNQKFAN SLSGVQQQLQ AFTAYCTLEK 360
PVKFQEKGNL EVLLFSIQSK LRAHNRRLFV PREGCGIWDI DKAWGELEKA EHEREAALRA 420
ELIRQEKLEL LAQRFDHKVA MRESWLNENQ RLVSQDNFGY ELPAVEAAMK KHEAIEADIA 480
AYEERVQGVA ELAQALAAEG YYDARRVAAQ RDSVLRQWAL LTGLVGARRT RLEQNLALQK 540
VFQEMVYMVD WMEEMQTQLL SRECGQHLVE ADDLLQKHGL LEGDIAAQSE RVEALNAAAL 600
RFSQLQGYQP CDPQVICNRV NHVHGCLSEL QEQAARRRAE LEASRSLWAL LQELEEAESW 660
ARDKERLLEA TSGSGGAAGT AGGAHDLSST ARLLAQHKIL QGELGGRRAL LQQALRRGEE 720
LAAAGGSVGP GAEPLHLAGL AERAASARRR WQRLEEAAAR RERRLQEARA LHQFGADLDG 780
LLDWLRDAYR LAAAGDFGHD EASSRRLARQ HRALTGEVEA HRGPVGGLRR QLATLGGASG 840
AGPLVVALQV RVVEAEQLFA EVTEVAALRR QWLRDALAVY RMFGEVHACE LWIGEKEQWL 900
LAMRVPDSLD DVEVVQHRFE SLDQEMNSLM GRVLDVNQTV QELVEGGHPS SDEVRSCQDH 960
LNSRWNRIVE LVEQRKEEMS AVLLVENHVL EVAEVRAQVR EKRRAVESAP RAGGALQWRL 1020
SGLEAALQAL EPRQAALLEE AALLAERFPA QATRLHQGAE ELGAEWGALA GAAQACGEAV 1080
AAAGRLQRFL RDLDTFLDWL VRAQEAAGAV EGPLPRSLEE ADGLLARHAA LKEEVDQREE 1140
DYARIVAASE ALLASEGAEL GPGLALDEWL PHLEVGWHKL LGLWEERREA LVQAHVYQLF 1200
LRDLCQALAV LRNQEVALSG AELPCTVESV EEAMKRHRDF LTTMELNQQK MQVAVQAAES 1260
LLRQGNAYGE QAQEAVARLL EKSQENQLRA QQWMQKLLDQ LVLQHFLRDC HELDGWIHEK 1320
MLMARDGTRE DSHKLHKRWL RHQAFMAELA QNKEWLEKIE REGQQLMQEK PELAASVRKK 1380
LGEIRQCWAE LESTTQAKAR QLFEASKADQ LVQSFAELDK RLLHMESQLQ DVDPGGDLAT 1440
VNSQLKKLQS MESQVEEWCR EVGELQAQTA ALPLEQASKE LVGERQSAVG ERLVRLLEPL 1500
QERRRLLLAS KELHQVAHDL DDELAWVQER LPLAMQTERG TGLQAVQQHI KKNQGLRREI 1560
QAHGPRLEEV LERAGVLASL RSPEAEAVRR GQEQLQSAWT GLREAAERRQ QTLDAAFQVE 1620
QYYFDVAEVE AWLGEQELLM MSEDKGKDEQ STLQLLKKHL QLEQGVENYE ESIAQLSRQC 1680
RALLEMGHPD SEQISRRQSQ VDRLYVALKE LGEERRVSLE QQYWLYQLSR QVDELEHWIA 1740
EKEVVAGSPE LGQDFEHVSV LQEKFSEFAS ETGTAGRERL AAVNQMVDEL IECGHTAAAT 1800
MAEWKDGLNE AWAELLELMG TRAQLLAASR ELHKFFSDAR ELQGQIEEKR RRLPRLTAPP 1860
EPRPSASSMQ RTLRAFEHDL QLLVSQVRQL QEGAAQLRTV YAGEHAEAIA SREQEVLQGW 1920
KELLAACEDA RLHVSSTADA LRFHSQARDL LSWMDGIAGQ IGAADKPRDV SSVEVLMNYH 1980
QGLKTELEAR VPELATCQEL GRSLLLNKSA MADEIQAQLD KLGSRKEEVS EKWDRHWEWL 2040
QQMLEVHQFA QEAVVADAWL TAQEPLLQSR ELGSSVDEVE QLIRRHEAFR KAAAAWEERF 2100
SSLRRLTTIE KLKAEQSKQP PTPLLGRKFF GDPTELAAKA APLLRPGGYD RGLEPLARRA 2160
SDTLSAEVRT RVGYVRQELK PERLQPRIDR LPETSGKVEP AAPTAAALDT TDTPGTPAAT 2220
ELVRPRSERQ ELADRAEELP RRRRSERQES VDQPEETARR RRPERQESAD HEGPHSLTLG 2280
RYEQMERRRE RRERRIERQE SSEQETPTRG ELVKGKATLA DIVEQLQEKE AGPGIPAGVP 2340
SLPQPRELPP GRLPNGLEPP ERTPRPDRPR ARDRPKPRRR PRPREGGEGG GSRRSRSAPA 2400
QGGSAPAPPP PPTHTVQHEG FLLRKRELDA NRKSSNRSWV SLYCVLSKGE LGFYKDSKGP 2460
ASGGTHGGEP LLSLHKATSE VASDYKKKKH VFKLQTQDGS EFLLQAKDEE EMNGWLEAVA 2520
NSVAEHAEIA RWGQTLPTTS STDEGNPKRE GGERRASGRR K 2561 
Gene Ontology
 GO:0043203; C:axon hillock; IDA:MGI.
 GO:0043194; C:axon initial segment; IDA:MGI.
 GO:0070852; C:cell body fiber; IDA:MGI.
 GO:0016020; C:membrane; IEA:Compara.
 GO:0016363; C:nuclear matrix; IEA:Compara.
 GO:0033270; C:paranode region of axon; IDA:MGI.
 GO:0016605; C:PML body; IEA:Compara.
 GO:0008091; C:spectrin; IEA:Compara.
 GO:0003779; F:actin binding; IDA:MGI.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0030507; F:spectrin binding; IDA:MGI.
 GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
 GO:0007628; P:adult walking behavior; IMP:MGI.
 GO:0061337; P:cardiac conduction; IMP:MGI.
 GO:0034613; P:cellular protein localization; IMP:MGI.
 GO:0021952; P:central nervous system projection neuron axonogenesis; IMP:MGI.
 GO:0045162; P:clustering of voltage-gated sodium channels; IMP:MGI.
 GO:0009566; P:fertilization; IMP:MGI.
 GO:0010459; P:negative regulation of heart rate; IMP:MGI.
 GO:0040018; P:positive regulation of multicellular organism growth; IMP:MGI.
 GO:0033135; P:regulation of peptidyl-serine phosphorylation; IDA:MGI.
 GO:0002028; P:regulation of sodium ion transport; IMP:MGI.
 GO:0007605; P:sensory perception of sound; IMP:MGI.
 GO:0019226; P:transmission of nerve impulse; IMP:MGI. 
Interpro
 IPR001589; Actinin_actin-bd_CS.
 IPR001715; CH-domain.
 IPR001605; PH_dom-spectrin-type.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR018159; Spectrin/alpha-actinin.
 IPR016343; Spectrin_bsu.
 IPR002017; Spectrin_repeat. 
Pfam
 PF00307; CH
 PF00169; PH
 PF00435; Spectrin 
SMART
 SM00033; CH
 SM00233; PH
 SM00150; SPEC 
PROSITE
 PS00019; ACTININ_1
 PS00020; ACTININ_2
 PS50021; CH
 PS50003; PH_DOMAIN 
PRINTS
 PR00683; SPECTRINPH.