UniProt Accession

 SFXN4_HUMAN; Q6P4A7; Q6WSU4; Q86TD9 

Genbank Protein ID

 AF336980; AY269785; AL355598; AL355861; AL355861; AL355598; BC063562 

Genbank Nucleotide ID

 AAP23066.1; AAP97074.1; CAI14126.1; CAI14126.1; CAI15801.1; CAI15801.1; AAH63562.1 

Protein Name

 Sideroflexin-4 

Protein Synonyms/Alias

 Breast cancer resistance marker 1 

Gene Name

 SFXN4 

Gene Synonyms/Alias

 BCRM1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
106	DSSNLIPKLFRPAAF	ubiquitination	[1, 2]
197	GLTGPWIKRLLPVIF	acetylation	[3]
197	GLTGPWIKRLLPVIF	ubiquitination	[1, 2]
223	SRSLESIKGIAVMDK	ubiquitination	[4]
230	KGIAVMDKEGNVLGH	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Potential iron transporter (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.
 MOD_RES 197 197 N6-acetyllysine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Ion transport; Iron; Iron transport; Membrane; Mitochondrion; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 337 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
 GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
 GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW. 

Interpro

 IPR004686; Mtc. 

Pfam

 PF03820; Mtc 

SMART

  

PROSITE

  

PRINTS