UniProt Accession

 MLAC_ECOLI; P0ADV7; P45390; Q2M920 

Genbank Protein ID

 U18997; U00096; AP009048 

Genbank Nucleotide ID

 AAA57993.1; AAC76224.1; BAE77236.1 

Protein Name

 Probable phospholipid-binding protein MlaC 

Protein Synonyms/Alias

  

Gene Name

 mlaC 

Gene Synonyms/Alias

 yrbC; b3192; JW3159 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
37	LMDEAAQKTFDRLKN	acetylation	[1]
83	LVLGQYYKSATPAQR	acetylation	[1]
188	WGTLLRTKGIDGLTA	acetylation	[1]
198	DGLTAQLKSISQQKI	acetylation	[1]
210	QKITLEEKK******	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. May transfer phospholipid across the periplasmic space and deliver it to the MlaFEDB complex at the inner membrane. 

Sequence Annotation

  

Keyword

 Complete proteome; Periplasm; Reference proteome; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 211 AA 

Protein Sequence

Gene Ontology

 GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
 GO:0005543; F:phospholipid binding; IMP:EcoCyc.
 GO:0015914; P:phospholipid transport; IMP:EcoCyc. 

Interpro

 IPR023094; Tol_tolerance_alpha.
 IPR008869; Ttg2/MlaC. 

Pfam

 PF05494; Tol_Tol_Ttg2 

SMART

  

PROSITE

  

PRINTS