| Tag | Content |
|---|
| CPLM ID | CPLM-022006 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein Jade-2 |
Protein Synonyms/Alias | PHD finger protein 15 |
Gene Name | PHF15 |
Gene Synonyms/Alias | JADE2; KIAA0239 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 32 | TSASRCSKLPSSTKS | acetylation | [1] |
|
Reference | [1] Proteome-wide prediction of acetylation substrates. Basu A, Rose KL, Zhang J, Beavis RC, Ueberheide B, Garcia BA, Chait B, Zhao Y, Hunt DF, Segal E, Allis CD, Hake SB. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13785-90. [ PMID: 19666589] |
Functional Description | Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. |
Sequence Annotation | ZN_FING 199 249 PHD-type.
MOD_RES 32 32 N6-acetyllysine.
MOD_RES 38 38 N6-acetyllysine.
MOD_RES 298 298 N6-acetyllysine. |
Keyword | Acetylation; Alternative splicing; Complete proteome; Metal-binding; Polymorphism; Reference proteome; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 790 AA |
Protein Sequence | MEEKRRKYSI SSDNSDTTDS HATSTSASRC SKLPSSTKSG WPRQNEKKPS EVFRTDLITA 60
MKIPDSYQLS PDDYYILADP WRQEWEKGVQ VPAGAEAIPE PVVRILPPLE GPPAQASPSS 120
TMLGEGSQPD WPGGSRYDLD EIDAYWLELI NSELKEMERP ELDELTLERV LEELETLCHQ 180
NMARAIETQE GLGIEYDEDV VCDVCRSPEG EDGNEMVFCD KCNVCVHQAC YGILKVPTGS 240
WLCRTCALGV QPKCLLCPKR GGALKPTRSG TKWVHVSCAL WIPEVSIGCP EKMEPITKIS 300
HIPASRWALS CSLCKECTGT CIQCSMPSCV TAFHVTCAFD HGLEMRTILA DNDEVKFKSF 360
CQEHSDGGPR NEPTSEPTEP SQAGEDLEKV TLRKQRLQQL EEDFYELVEP AEVAERLDLA 420
EALVDFIYQY WKLKRKANAN QPLLTPKTDE VDNLAQQEQD VLYRRLKLFT HLRQDLERVR 480
NLCYMVTRRE RTKHAICKLQ EQIFHLQMKL IEQDLCRERS GRRAKGKKSD SKRKGCEGSK 540
GSTEKKEKVK AGPDSVLGQL GE 562 |
Gene Ontology | GO:0000123; C:histone acetyltransferase complex; IDA:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0043966; P:histone H3 acetylation; IDA:UniProtKB. GO:0043983; P:histone H4-K12 acetylation; IDA:UniProtKB. GO:0043981; P:histone H4-K5 acetylation; IDA:UniProtKB. GO:0043982; P:histone H4-K8 acetylation; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |