Tag | Content |
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CPLM ID | CPLM-020714 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase MGRN1 |
Protein Synonyms/Alias | Mahogunin RING finger protein 1 |
Gene Name | Mgrn1 |
Gene Synonyms/Alias | Kiaa0544 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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101 | SLRLVRYKEDADSPT | ubiquitination | [1] | 164 | QSETVHYKRGVSQQF | ubiquitination | [1] | 235 | VDGSFSVKPLKQKQI | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | E3 ubiquitin-protein ligase. Mediates TSG101 monoubiquitination at multiple sites. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination (By similarity). |
Sequence Annotation | ZN_FING 277 316 RING-type. MOTIF 384 387 Required for TSG101-binding. MOD_RES 501 501 Phosphoserine (By similarity). LIPID 2 2 N-myristoyl glycine (By similarity). |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Endosome; Ligase; Lipoprotein; Membrane; Metal-binding; Myristate; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 532 AA |
Protein Sequence | MGSILSRRIA GVEDIDIQAN SAYRYPPKSG NYFASHFFMG GEKFDTPHPE GYLFGENMDL 60 NFLGSRPVQF PYVTPAPHEP VKTLRSLVNI RKDSLRLVRY KEDADSPTED GEKPRVLYSL 120 EFTFDADARV AITIYCQAVE ELVNGVAVYS CKNPSLQSET VHYKRGVSQQ FSLPSFKIDF 180 SEWKDDELNF DLDRGVFPVV IQAVVDEGDV VEVTGHAHVL LAAFEKHVDG SFSVKPLKQK 240 QIVDRVSYLL QEIYGIENKN NQETKPSDDE NSDNSSECVV CLSDLRDTLI LPCRHLCLCT 300 SCADTLRYQA NNCPICRLPF RALLQIRAVR KKPGALSPIS FSPVLAQSVD HDEHSSSDSI 360 PPGYEPISLL EALNGLRAVS PAIPSAPLYE EITYSGISDG LSQASCPLAG LDRIMESGLQ 420 KGKTQSKSPD STLRSPSFPI HEEDEEKLSE DSDAPLPPSG VELVLRESSS PESFGTEEGD 480 EPSLKQGSRV PSIDDVLQDG SPQHHGCSQP VPPADIYLPA LGPESCSVGI EE 532 |
Gene Ontology | GO:0005769; C:early endosome; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0008333; P:endosome to lysosome transport; IEA:Compara. GO:0043951; P:negative regulation of cAMP-mediated signaling; ISS:UniProtKB. GO:0045744; P:negative regulation of G-protein coupled receptor protein signaling pathway; ISS:UniProtKB. GO:0006513; P:protein monoubiquitination; IEA:Compara. GO:0000209; P:protein polyubiquitination; IDA:MGI. |
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