CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029945
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Growth factor receptor-bound protein 2 
Protein Synonyms/Alias
  
Gene Name
 Grb2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
10AIAKYDFKATADDELubiquitination[1]
50GKDGFIPKNYIEMKPacetylation[2, 3, 4]
109GNDVQHFKVLRDGAGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 203 AA 
Protein Sequence
MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW 60
FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL 120
WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQMPQEDGE LGFRRGDFIH VMDNSDPNWW 180
KGACHGQTGM FPRNYVTPVN RNV 203 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0012506; C:vesicle membrane; IDA:MGI.
 GO:0005070; F:SH3/SH2 adaptor activity; IDA:MGI.
 GO:0048646; P:anatomical structure formation involved in morphogenesis; IMP:MGI.
 GO:0060670; P:branching involved in labyrinthine layer morphogenesis; IMP:MGI.
 GO:0030154; P:cell differentiation; IMP:MGI.
 GO:0030838; P:positive regulation of actin filament polymerization; IGI:MGI.
 GO:0007265; P:Ras protein signal transduction; TAS:MGI.
 GO:0043408; P:regulation of MAPK cascade; IGI:MGI. 
Interpro
 IPR000980; SH2.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 
Pfam
 PF00017; SH2
 PF00018; SH3_1
 PF07653; SH3_2 
SMART
 SM00252; SH2
 SM00326; SH3 
PROSITE
 PS50001; SH2
 PS50002; SH3 
PRINTS
 PR00401; SH2DOMAIN.
 PR00452; SH3DOMAIN.