| Tag | Content |
|---|
| CPLM ID | CPLM-015454 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nostrin |
Protein Synonyms/Alias | Disabled homolog 2-interacting protein 2; Dab2-interacting protein 2; Nitric oxide synthase trafficker; eNOS-trafficking inducer |
Gene Name | Nostrin |
Gene Synonyms/Alias | Daip2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 88 | SAADLHQKLGKAIEL | ubiquitination | [1] | | 190 | EDESYYQKNMAGYST | ubiquitination | [1] | | 328 | EGLERKLKALASSSS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane (By similarity). |
Sequence Annotation | DOMAIN 1 66 FCH.
DOMAIN 438 497 SH3.
MOD_RES 479 479 Phosphoserine. |
Keyword | Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Endocytosis; Membrane; Nucleus; Phosphoprotein; Reference proteome; SH3 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 506 AA |
Protein Sequence | MRDPLTDCSY NKVYKSLKEF AQHGDNFCKQ ITSVLQQRAN LEISYAKGLQ KLAVRLSKAL 60
QSTKKNCLST AWAWASESMK SAADLHQKLG KAIELEAIKP THQVLSMQEK KRKSLDNEVE 120
KTANLVINNW NQQIKAKKKL MMSTKKHEAL FHLVESSKQS LTQKEKQKLL NKLKKSTEKL 180
EKEDESYYQK NMAGYSTRLK WESTLENCYK SMLELEKERI QLLCNNLNQY SQHISLFGQT 240
LTTCHTQIHC AISKVDVEKD IQALMEETAI LSIENKSELL LADYFEEDPK NPMDKERRKS 300
LLKPKLGRLQ RDIEKASRDK EGLERKLKAL ASSSSFSDAK SQKDMETLMD ENSLKLDLLQ 360
ANSYKLSSVL ADLEQRPKPC HPCSTCIFKW KEKEHSHTYV KISRPLLTKR LEKAESKAPA 420
GGQNNPSSSP SGSTVSQASK HLCKALYTFQ ARQDDELNLE KGDIVTVHEK KEEGWWFGSL 480
KGKRGHFPAA YVEELPPKAG NTATQA 506 |
Gene Ontology | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IDA:MGI. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; IDA:MGI. GO:0006897; P:endocytosis; IEA:UniProtKB-KW. GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |