CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000420
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ataxin-7 
Protein Synonyms/Alias
 Spinocerebellar ataxia type 7 protein 
Gene Name
 ATXN7 
Gene Synonyms/Alias
 SCA7 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
257RIMTPSVKVEKIHPKacetylation[1]
257RIMTPSVKVEKIHPKsumoylation[2]
438GVIPSESKPFVASKPacetylation[3]
Reference
 [1] Posttranslational modification of ataxin-7 at lysine 257 prevents autophagy-mediated turnover of an N-terminal caspase-7 cleavage fragment.
 Mookerjee S, Papanikolaou T, Guyenet SJ, Sampath V, Lin A, Vitelli C, DeGiacomo F, Sopher BL, Chen SF, La Spada AR, Ellerby LM.
 J Neurosci. 2009 Dec 2;29(48):15134-44. [PMID: 19955365]
 [2] SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7.
 Janer A, Werner A, Takahashi-Fujigasaki J, Daret A, Fujigasaki H, Takada K, Duyckaerts C, Brice A, Dejean A, Sittler A.
 Hum Mol Genet. 2010 Jan 1;19(1):181-95. [PMID: 19843541]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
 Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization. 
Sequence Annotation
 DOMAIN 334 401 SCA7.
 CROSSLNK 257 257 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Isopeptide bond; Neurodegeneration; Nucleus; Polymorphism; Reference proteome; Spinocerebellar ataxia; Transcription; Transcription regulation; Triplet repeat expansion; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 892 AA 
Protein Sequence
MSERAADDVR GEPRRAAAAA GGAAAAAARQ QQQQQQQQQP PPPQPQRQQH PPPPPRRTRP 60
EDGGPGAAST SAAAMATVGE RRPLPSPEVM LGQSWNLWVE ASKLPGKDGT ELDESFKEFG 120
KNREVMGLCR EDMPIFGFCP AHDDFYLVVC NDCNQVVKPQ AFQSHYERRH SSSSKPPLAV 180
PPTSVFSFFP SLSKSKGGSA SGSNRSSSGG VLSASSSSSK LLKSPKEKLQ LRGNTRPMHP 240
IQQSRVPHGR IMTPSVKVEK IHPKMDGTLL KSAVGPTCPA TVSSLVKPGL NCPSIPKPTL 300
PSPGQILNGK GLPAPPTLEK KPEDNSNNRK FLNKRLSERE FDPDIHCGVI DLDTKKPCTR 360
SLTCKTHSLT QRRAVQGRRK RFDVLLAEHK NKTREKELIR HPDSQQPPQP LRDPHPAPPR 420
TSQEPHQNPH GVIPSESKPF VASKPKPHTP SLPRPPGCPA QQGGSAPIDP PPVHESPHPP 480
LPATEPASRL SSEEGEGDDK EESVEKLDCH YSGHHPQPAS FCTFGSRQIG RGYYVFDSRW 540
NRLRCALNLM VEKHLNAQLW KKIPPVPSTT SPISTRIPHR TNSVPTSQCG VSYLAAATVS 600
TSPVLLSSTC ISPNSKSVPA HGTTLNAQPA ASGAMDPVCS MQSRQVSSSS SSPSTPSGLS 660
SVPSSPMSRK PQKLKSSKSL RPKESSGNST NCQNASSSTS GGSGKKRKNS SPLLVHSSSS 720
SSSSSSSSHS MESFRKNCVA HSGPPYPSTV TSSHSIGLNC VTNKANAVNV RHDQSGRGPP 780
TGSPAESIKR MSVMVNSSDS TLSLGPFIHQ SNELPVNSHG SFSHSHTPLD KLIGKKRKCS 840
PSSSSINNSS SKPTKVAKVP AVNNVHMKHT GTIPGAQGLM NSSLLHQPKA RP 892 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0015630; C:microtubule cytoskeleton; IDA:UniProtKB.
 GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0016578; P:histone deubiquitination; IDA:UniProtKB.
 GO:0000226; P:microtubule cytoskeleton organization; IMP:UniProtKB.
 GO:0043569; P:negative regulation of insulin-like growth factor receptor signaling pathway; IEA:Compara.
 GO:0042326; P:negative regulation of phosphorylation; IEA:Compara.
 GO:0006997; P:nucleus organization; TAS:ProtInc.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0007601; P:visual perception; TAS:ProtInc. 
Interpro
 IPR013243; SCA7_dom.
 IPR015880; Znf_C2H2-like. 
Pfam
 PF08313; SCA7 
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS51505; SCA7 
PRINTS