| Tag | Content |
|---|
| CPLM ID | CPLM-018642 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase |
Protein Synonyms/Alias | Alpha-2,8-sialyltransferase 8D; Polysialyltransferase-1; Sialyltransferase 8D; SIAT8-D; Sialyltransferase St8Sia IV; ST8SiaIV |
Gene Name | ST8SIA4 |
Gene Synonyms/Alias | PST; PST1; SIAT8D |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 99 | ERDVSVVKSSFKPGD | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells. |
Sequence Annotation | CARBOHYD 50 50 N-linked (GlcNAc...) (Potential).
CARBOHYD 74 74 N-linked (GlcNAc...).
CARBOHYD 119 119 N-linked (GlcNAc...) (Potential).
CARBOHYD 204 204 N-linked (GlcNAc...) (Potential).
CARBOHYD 219 219 N-linked (GlcNAc...) (Potential).
CARBOHYD 327 327 N-linked (GlcNAc...) (Potential).
DISULFID 142 292
DISULFID 156 356 |
Keyword | Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Glycosyltransferase; Golgi apparatus; Membrane; Polymorphism; Reference proteome; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 359 AA |
Protein Sequence | MRSIRKRWTI CTISLLLIFY KTKEIARTEE HQETQLIGDG ELSLSRSLVN SSDKIIRKAG 60
SSIFQHNVEG WKINSSLVLE IRKNILRFLD AERDVSVVKS SFKPGDVIHY VLDRRRTLNI 120
SHDLHSLLPE VSPMKNRRFK TCAVVGNSGI LLDSECGKEI DSHNFVIRCN LAPVVEFAAD 180
VGTKSDFITM NPSVVQRAFG GFRNESDREK FVHRLSMLND SVLWIPAFMV KGGEKHVEWV 240
NALILKNKLK VRTAYPSLRL IHAVRGYWLT NKVPIKRPST GLLMYTLATR FCDEIHLYGF 300
WPFPKDLNGK AVKYHYYDDL KYRYFSNASP HRMPLEFKTL NVLHNRGALK LTTGKCVKQ 359 |
Gene Ontology | GO:0000139; C:Golgi membrane; TAS:Reactome. GO:0030173; C:integral to Golgi membrane; IEA:InterPro. GO:0003828; F:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity; IDA:BHF-UCL. GO:0033691; F:sialic acid binding; IC:BHF-UCL. GO:0007411; P:axon guidance; TAS:Reactome. GO:0001574; P:ganglioside biosynthetic process; IDA:BHF-UCL. GO:0006491; P:N-glycan processing; IDA:BHF-UCL. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |