UniProt Accession

 HINT3_MOUSE; Q9CPS6 

Genbank Protein ID

 AY040768; AK002482; AK007758; AK027974; BC025065 

Genbank Nucleotide ID

 AAK94778.1; BAB22134.1; BAB25237.1; BAC25684.1; AAH25065.1 

Protein Name

 Histidine triad nucleotide-binding protein 3 

Protein Synonyms/Alias

 HINT-3; HINT-4 

Gene Name

 Hint3 

Gene Synonyms/Alias

 Hint4 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
61	LVCFKDIKPAALYHY	ubiquitination	[1]
80	KKHIGSCKDLNKDHI	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Hydrolyzes phosphoramidate and acyl-adenylate substrates. 

Sequence Annotation

 DOMAIN 32 143 HIT.
 NP_BIND 59 60 Purine nucleotide phosphoramidate (By
 NP_BIND 128 130 Purine nucleotide phosphoramidate (By
 MOTIF 126 130 Histidine triad motif.
 ACT_SITE 128 128 Tele-AMP-histidine intermediate (By
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Hydrolase; Nucleotide-binding; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 165 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0008152; P:metabolic process; IEA:GOC. 

Interpro

 IPR001310; Histidine_triad_HIT.
 IPR011146; HIT-like. 

Pfam

  

SMART

  

PROSITE

 PS00892; HIT_1
 PS51084; HIT_2 

PRINTS