UniProt Accession

 NDUAA_HUMAN; O95299 

Genbank Protein ID

 AF087661; BC003417 

Genbank Nucleotide ID

 AAD09755.1; AAH03417.1 

Protein Name

 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial 

Protein Synonyms/Alias

 Complex I-42kD; CI-42kD; NADH-ubiquinone oxidoreductase 42 kDa subunit 

Gene Name

 NDUFA10 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
48	WHFLLGDKASKRLTE	ubiquitination	[1]
102	DSTTGDGKPLATDYN	ubiquitination	[1]
242	QDIENAYKKTFLPEM	ubiquitination	[2]
243	DIENAYKKTFLPEMS	ubiquitination	[1]
277	VEDIEYLKFDKGPWL	ubiquitination	[1, 2, 3]
280	IEYLKFDKGPWLKQD	ubiquitination	[1]
285	FDKGPWLKQDNRTLY	ubiquitination	[1, 2, 3]
338	FRELPGRKYSPGYNT	ubiquitination	[3]
350	YNTEVGDKWIWLK**	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. 

Sequence Annotation

 MOD_RES 181 181 N6-acetyllysine (By similarity).
 MOD_RES 242 242 N6-acetyllysine (By similarity).
 MOD_RES 350 350 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Electron transport; FAD; Flavoprotein; Mitochondrion; Polymorphism; Reference proteome; Respiratory chain; Transit peptide; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 355 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005747; C:mitochondrial respiratory chain complex I; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; NAS:UniProtKB.
 GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
 GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; NAS:UniProtKB.
 GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR002624; Deoxynucleoside_kinase.
 IPR015828; NADH_UbQ_OxRdtase_42KD_su.
 IPR027417; P-loop_NTPase. 

Pfam

 PF01712; dNK 

SMART

  

PROSITE

  

PRINTS