CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033226
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 LIM and SH3 domain protein 1 
Protein Synonyms/Alias
  
Gene Name
 LASP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
6**MTLNMKNYKGYEKacetylation[1]
6**MTLNMKNYKGYEKubiquitination[2]
9TLNMKNYKGYEKKPYubiquitination[3]
39TPENLRLKQQSELQSmethylation[4]
39TPENLRLKQQSELQSubiquitination[2, 5]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 166 AA 
Protein Sequence
MTLNMKNYKG YEKKPYCNAH YPKQSFTMVA DTPENLRLKQ QSELQSQVRY KEEFEKNKGK 60
GFSVVADTPE LQRIKKTQDQ ISNIKYHEEF EKSRMGPSGG EGMEPERRDS QDGSSYRRPL 120
EQQQPHHIPT SAPVYQQPQQ QPVAQSYGGY KEPAAPVSIQ RSAPGG 166 
Gene Ontology
 GO:0030864; C:cortical actin cytoskeleton; IEA:Compara.
 GO:0005925; C:focal adhesion; IEA:Compara.
 GO:0015075; F:ion transmembrane transporter activity; IEA:Compara. 
Interpro
 IPR000900; Nebulin_35r-motif. 
Pfam
 PF00880; Nebulin 
SMART
 SM00227; NEBU 
PROSITE
 PS51216; NEBULIN 
PRINTS