UniProt Accession

 DAP1_HUMAN; P51397; Q6FGC3; Q9BUC9 

Genbank Protein ID

 X76105; CR542184; AY266680; BC002726 

Genbank Nucleotide ID

 CAA53713.1; CAG46981.1; AAO89078.1; AAH02726.2 

Protein Name

 Death-associated protein 1 

Protein Synonyms/Alias

 DAP-1 

Gene Name

 DAP 

Gene Synonyms/Alias

 DAP1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
29	GGMRIVQKHPHTGDT	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.
 MOD_RES 3 3 Phosphoserine; by MTOR.
 MOD_RES 49 49 Phosphoserine.
 MOD_RES 51 51 Phosphoserine; by MTOR.
 MOD_RES 91 91 Phosphoserine.  

Keyword

 Acetylation; Apoptosis; Autophagy; Complete proteome; Direct protein sequencing; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 102 AA 

Protein Sequence

Gene Ontology

 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.
 GO:0097190; P:apoptotic signaling pathway; IMP:UniProtKB.
 GO:0006914; P:autophagy; IEA:UniProtKB-KW.
 GO:0034198; P:cellular response to amino acid starvation; IDA:UniProtKB.
 GO:0010507; P:negative regulation of autophagy; IMP:UniProtKB.
 GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IMP:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:UniProtKB. 

Interpro

 IPR024130; DAP1/DAPL1. 

Pfam

  

SMART

  

PROSITE

  

PRINTS