UniProt Accession

 PRS7_YEAST; P33299; D6VX51 

Genbank Protein ID

 Z22817; X73571; Z28145; BK006944 

Genbank Nucleotide ID

 CAA80470.1; CAA51973.1; CAA81986.1; DAA09017.1 

Protein Name

 26S protease regulatory subunit 7 homolog 

Protein Synonyms/Alias

 Protein CIM5; Tat-binding homolog 3 

Gene Name

 RPT1 

Gene Synonyms/Alias

 CIM5; YTA3; YKL145W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
38	EGDIQVLKSYGAAPY	acetylation	[1]
48	GAAPYAAKLKQTEND	acetylation	[1]
48	GAAPYAAKLKQTEND	ubiquitination	[2]
107	ARCTKIIKGNGESDE	ubiquitination	[3]
150	AKYVINLKQIAKFVV	acetylation	[1]
154	INLKQIAKFVVGLGE	ubiquitination	[2]
282	IGSELVQKYVGEGAR	ubiquitination	[2]
374	RPGRIDRKVEFSLPD	ubiquitination	[2]
394	NIFRIHSKSMSVERG	ubiquitination	[2]
441	RRKVATEKDFLKAVD	ubiquitination	[2]
449	DFLKAVDKVISGYKK	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [3] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 

Functional Description

 The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). 

Sequence Annotation

 NP_BIND 250 257 ATP (Potential).
 MOD_RES 164 164 Phosphoserine.
 MOD_RES 231 231 Phosphoserine.  

Keyword

 3D-structure; ATP-binding; Complete proteome; Cytoplasm; Nucleotide-binding; Nucleus; Phosphoprotein; Proteasome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 467 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0008540; C:proteasome regulatory particle, base subcomplex; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; ISS:SGD.
 GO:0045732; P:positive regulation of protein catabolic process; IDA:SGD.
 GO:0045899; P:positive regulation of RNA polymerase II transcriptional preinitiation complex assembly; IMP:SGD.
 GO:0070682; P:proteasome regulatory particle assembly; IMP:SGD.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IPI:SGD. 

Interpro

 IPR005937; 26S_Psome_P45.
 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR003960; ATPase_AAA_CS.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00004; AAA 

SMART

 SM00382; AAA 

PROSITE

 PS00674; AAA 

PRINTS