| Tag | Content |
|---|
| CPLM ID | CPLM-009953 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Stromal interaction molecule 1 |
Protein Synonyms/Alias | |
Gene Name | Stim1 |
Gene Synonyms/Alias | Sim |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 333 | EALRKAEKELESHSS | ubiquitination | [1] | | 413 | DHKILTAKQALSEVT | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1 (By similarity). |
Sequence Annotation | DOMAIN 63 98 EF-hand.
DOMAIN 132 200 SAM.
REGION 334 444 SOAR/CAD (By similarity).
MOTIF 642 645 Microtubule tip localization signal.
MOD_RES 257 257 Phosphoserine.
MOD_RES 519 519 Phosphoserine.
MOD_RES 524 524 Phosphoserine.
MOD_RES 575 575 Phosphoserine (By similarity).
MOD_RES 608 608 Phosphoserine (By similarity).
MOD_RES 660 660 Phosphoserine (By similarity).
MOD_RES 665 665 Phosphothreonine.
MOD_RES 668 668 Phosphoserine.
CARBOHYD 131 131 N-linked (GlcNAc...) (Potential).
CARBOHYD 171 171 N-linked (GlcNAc...) (Potential). |
Keyword | Calcium; Calcium transport; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Endoplasmic reticulum; Glycoprotein; Ion transport; Membrane; Metal-binding; Microtubule; Phosphoprotein; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 685 AA |
Protein Sequence | MDVCARLALW LLWGLLLHQG QSLSHSHSEK NTGASSGATS EESTEAEFCR IDKPLCHSED 60
EKLSFEAVRN IHKLMDDDAN GDVDVEESDE FLREDLNYHD PTVKHSTFHG EDKLISVEDL 120
WKAWKSSEVY NWTVDEVIQW LITYVELPQY EETFRKLQLT GHAMPRLAVT NTTMTGTVLK 180
MTDRSHRQKL QLKALDTVLF GPPLLTRHNH LKDFMLVVSI VIGVGGCWFA YIQNRYSKEH 240
MKKMMKDLEG LHRAEQSLHD LQERLHKAQE EHRTVEVEKV HLEKKLRDEI NLAKQEAQRL 300
KELREGTENE RSRQKYAEEE LEQVREALRK AEKELESHSS WYAPEALQKW LQLTHEVEVQ 360
YYNIKKQNAE RQLLVAKEGA EKIKKKRNTL FGTFHVAHSS SLDDVDHKIL TAKQALSEVT 420
AALRERLHRW QQIEILCGFQ IVNNPGIHSL VAALNIDPSW MGSTRPNPAH FIMTDDVDDM 480
DEEIVSPLSM QSPSLQSSVR QRLTEPQLGL GSQRDLTHSD SESSLHMSDR QRVAPKPPQM 540
GRAADEALNA MPSNGSHRLI EGVHPGSLVE KLPDSPALAK KTFMALNHGL DKAHSLMELN 600
PSVPPGGSPL LDSSHSLSPS SPDPDTPSPV GDNRALQGSR NTRIPHLAGK KAMAEEDNGS 660
IGEETDSSPG RKKFPLKIFK KPLKK 685 |
Gene Ontology | GO:0032541; C:cortical endoplasmic reticulum; IEA:Compara. GO:0030176; C:integral to endoplasmic reticulum membrane; ISS:UniProtKB. GO:0005887; C:integral to plasma membrane; ISS:UniProtKB. GO:0005874; C:microtubule; IEA:UniProtKB-KW. GO:0043234; C:protein complex; IPI:MGI. GO:0005509; F:calcium ion binding; ISS:UniProtKB. GO:0051010; F:microtubule plus-end binding; ISS:UniProtKB. GO:0032237; P:activation of store-operated calcium channel activity; ISS:UniProtKB. GO:0006816; P:calcium ion transport; IEA:UniProtKB-KW. GO:0006812; P:cation transport; IMP:MGI. GO:0005513; P:detection of calcium ion; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |