CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029191
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Gelsolin 
Protein Synonyms/Alias
  
Gene Name
 Gsn 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
126GGVASGFKHVVPNEVubiquitination[1]
142VQRLFQVKGRRVVRAacetylation[2]
142VQRLFQVKGRRVVRAubiquitination[1]
194LKATQVSKGIRDNERubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 251 AA 
Protein Sequence
MVVEHPEFLK AGKEPGLQIW RVEKFDLVPV PPNLYGDFFT GDAYVILKTV QLRNGNLQYD 60
LHYWLGNECS QDESGAAAIF TVQLDDYLNG RAVQHREVQG FESSTFSGYF KSGLKYKKGG 120
VASGFKHVVP NEVVVQRLFQ VKGRRVVRAT EVPVSWDSFN NGDCFILDLG NNIYQWCGSG 180
SNKFERLKAT QVSKGIRDNE RSGRAQVHVS EEGGEPEAML QVLGPKPALP EGTEDTAKED 240
AANRRLAKLY K 251 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IEA:Compara.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0070062; C:extracellular vesicular exosome; IEA:Compara.
 GO:0030027; C:lamellipodium; IDA:MGI.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0001726; C:ruffle; IEA:Compara.
 GO:0008154; P:actin polymerization or depolymerization; IEA:Compara.
 GO:0007568; P:aging; IEA:Compara.
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0071276; P:cellular response to cadmium ion; IEA:Compara.
 GO:0060271; P:cilium morphogenesis; IEA:Compara.
 GO:0014003; P:oligodendrocyte development; IEA:Compara.
 GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:Compara.
 GO:0030155; P:regulation of cell adhesion; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0051593; P:response to folic acid; IEA:Compara.
 GO:0042246; P:tissue regeneration; IEA:Compara.
 GO:0016192; P:vesicle-mediated transport; IMP:MGI. 
Interpro
 IPR007123; Gelsolin_dom.
 IPR007122; Villin/Gelsolin. 
Pfam
 PF00626; Gelsolin 
SMART
 SM00262; GEL 
PROSITE
  
PRINTS
 PR00597; GELSOLIN.