| Tag | Content |
|---|
| CPLM ID | CPLM-008773 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ubiquitin carboxyl-terminal hydrolase 10 |
Protein Synonyms/Alias | Deubiquitinating enzyme 10; Disrupter of telomere silencing protein 4; Ubiquitin thioesterase 10; Ubiquitin-specific-processing protease 10 |
Gene Name | UBP10 |
Gene Synonyms/Alias | DOT4; YNL186W; N1619 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 428 | PVSKNPRKNVSASYI | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Has a role in telomere and HM loci silencing, which is the repression of chromatin structure which leads to a stop in the transcription of nearby genes. |
Sequence Annotation | ACT_SITE 371 371 Nucleophile (By similarity).
ACT_SITE 691 691 Proton acceptor (By similarity). |
Keyword | Chromosome; Complete proteome; Hydrolase; Protease; Reference proteome; Telomere; Thiol protease; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 792 AA |
Protein Sequence | MTTQESIKPL VDRILSNPLQ FNAAMISNKS NNNDTSAAPE NSSYIVIGKQ HNNNSNSTAI 60
AATAESKQIK ENNLIDRPNG KKTNTVPKSM AEALLLYTSK NDKDAADATG AKKSAELSTE 120
LSTEPPSSSS EDDKVGKEEE EEGEIFHEAR DYVEPRKASL KERDNADKGD GEDIGEDIGE 180
DIGEDIGEDI GEDIGENLGS PLATIDDSSN ENEKEKRKEL STSISSDDEI EDDEDEDDMD 240
YDSSAMEKEL PEEEENDSSS KISEGEKKSL YQDLMENSTV EVNRYEPVNN TKENGNRNPK 300
GEEEEEEEEE LKHKSRSITP PVTISNLSNF YQFNENINDR GSLNSTRIVK NWGDKFTNLK 360
PRGLLNHGVT CYTNAAVQAM LHIPSIQHYL FDILMGKYDS TISKNSVSYT LAETSKKMWL 420
PVSKNPRKNV SASYINPKHL ISRLDDINCM MSEWQQEDSH EYFMSLMSRL QEDSVPKGHK 480
LIESIIYDIF GGLLKQIVTC KSCGSISKTE QPFYDLSLHL KGKKKLDPNS DLSSDSINGT 540
SATTSTTTSN AATKPSLSSS SSVNLNNGSP FAAASDLSSA NRRFSIEKSI KDFFNPELIK 600
VDKEQKGYVC EKCHKTTNAV KHSSILRAPE TLLVHLKKFR FNGTSSSKMK QAVSYPMFLD 660
LTEYCESKEL PVKYQLLSVV VHEGRSLSSG HYIAHCKQPD GSWATYDDEY INIISERDVL 720
KEPNAYYLLY TRLTPKSVPL PLAKSAMATG NVTSKSKQEQ AVNEPNNRPL KINSKKNNRK 780
KWKKNKKRKF TK 792 |
Gene Ontology | GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IDA:SGD. GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro. GO:0004843; F:ubiquitin-specific protease activity; IDA:SGD. GO:0006348; P:chromatin silencing at telomere; IMP:SGD. GO:0016579; P:protein deubiquitination; IMP:SGD. GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |