CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000042
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Menin 
Protein Synonyms/Alias
  
Gene Name
 MEN1 
Gene Synonyms/Alias
 SCG2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
8MGLKAAQKTLFPLRSubiquitination[1]
120SSRELVKKVSDVIWNubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair. 
Sequence Annotation
 REGION 219 395 Interaction with FANCD2.
 MOD_RES 599 599 Phosphothreonine.  
Keyword
 3D-structure; Alternative splicing; Chromatin regulator; Complete proteome; Disease mutation; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 615 AA 
Protein Sequence
MGLKAAQKTL FPLRSIDDVV RLFAAELGRE EPDLVLLSLV LGFVEHFLAV NRVIPTNVPE 60
LTFQPSPAPD PPGGLTYFPV ADLSIIAALY ARFTAQIRGA VDLSLYPREG GVSSRELVKK 120
VSDVIWNSLS RSYFKDRAHI QSLFSFITGT KLDSSGVAFA VVGACQALGL RDVHLALSED 180
HAWVVFGPNG EQTAEVTWHG KGNEDRRGQT VNAGVAERSW LYLKGSYMRC DRKMEVAFMV 240
CAINPSIDLH TDSLELLQLQ QKLLWLLYDL GHLERYPMAL GNLADLEELE PTPGRPDPLT 300
LYHKGIASAK TYYRDEHIYP YMYLAGYHCR NRNVREALQA WADTATVIQD YNYCREDEEI 360
YKEFFEVAND VIPNLLKEAA SLLEAGEERP GEQSQGTQSQ GSALQDPECF AHLLRFYDGI 420
CKWEEGSPTP VLHVGWATFL VQSLGRFEGQ VRQKVRIVSR EAEAAEAEEP WGEEAREGRR 480
RGPRRESKPE EPPPPKKPAL DKGLGTGQGA VSGPPRKPPG TVAGTARGPE GGSTAQVPAP 540
TASPPPEGPV LTFQSEKMKG MKELLVATKI NSSAIKLQLT AQSQVQMKKQ KVSTPSDYTL 600
SFLKRQRKGL 610 
Gene Ontology
 GO:0000785; C:chromatin; IDA:UniProtKB.
 GO:0032154; C:cleavage furrow; IDA:UniProtKB.
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0035097; C:histone methyltransferase complex; IDA:MGI.
 GO:0016363; C:nuclear matrix; IDA:UniProtKB.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0003690; F:double-stranded DNA binding; IDA:UniProtKB.
 GO:0000400; F:four-way junction DNA binding; IDA:UniProtKB.
 GO:0030674; F:protein binding, bridging; IDA:UniProtKB.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
 GO:0000403; F:Y-form DNA binding; IDA:UniProtKB.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0007050; P:cell cycle arrest; IEA:Compara.
 GO:0006338; P:chromatin remodeling; IEA:Compara.
 GO:0006281; P:DNA repair; NAS:UniProtKB.
 GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Compara.
 GO:0030097; P:hemopoiesis; IEA:Compara.
 GO:0034968; P:histone lysine methylation; IDA:GOC.
 GO:0001776; P:leukocyte homeostasis; IEA:Compara.
 GO:0000165; P:MAPK cascade; IDA:UniProtKB.
 GO:0060135; P:maternal process involved in female pregnancy; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IDA:UniProtKB.
 GO:0045736; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity; IMP:UniProtKB.
 GO:0046329; P:negative regulation of JNK cascade; IDA:UniProtKB.
 GO:0046621; P:negative regulation of organ growth; IEA:Compara.
 GO:0045668; P:negative regulation of osteoblast differentiation; IGI:MGI.
 GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0051974; P:negative regulation of telomerase activity; IMP:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0002076; P:osteoblast development; IGI:MGI.
 GO:0002051; P:osteoblast fate commitment; IEA:Compara.
 GO:0060021; P:palate development; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0051781; P:positive regulation of cell division; IEA:Compara.
 GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0031062; P:positive regulation of histone methylation; IEA:Compara.
 GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Compara.
 GO:0032092; P:positive regulation of protein binding; IDA:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; TAS:Reactome.
 GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IMP:UniProtKB.
 GO:0032925; P:regulation of activin receptor signaling pathway; IEA:Compara.
 GO:0010332; P:response to gamma radiation; IDA:UniProtKB.
 GO:0009411; P:response to UV; IDA:UniProtKB.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:Reactome. 
Interpro
 IPR007747; Menin. 
Pfam
 PF05053; Menin 
SMART
  
PROSITE
  
PRINTS