| Tag | Content |
|---|
| CPLM ID | CPLM-013168 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ral guanine nucleotide dissociation stimulator-like 3 |
Protein Synonyms/Alias | RalGDS-like 3; RalGDS-related effector protein of M-Ras; Ras pathway modulator; RPM |
Gene Name | Rgl3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 140 | GQDLNFSKNLRAVVS | ubiquitination | [1] | | 191 | AEAREAEKLLEDFLK | ubiquitination | [1] | | 376 | EPLSVFRKLSQIFSD | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1. |
Sequence Annotation | DOMAIN 64 201 N-terminal Ras-GEF.
DOMAIN 248 503 Ras-GEF.
DOMAIN 612 699 Ras-associating.
REGION 611 706 Interaction with HRAS, MRAS and RIT1.
MOD_RES 506 506 Phosphoserine.
MOD_RES 510 510 Phosphoserine.
MOD_RES 568 568 Phosphoserine.
MOD_RES 572 572 Phosphoserine.
MOD_RES 600 600 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Direct protein sequencing; Guanine-nucleotide releasing factor; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 709 AA |
Protein Sequence | MERTAGKELA LAPLQDWGEE TEDGAVYSVS LRRQRSQRST PERSGEGQTP IPATDTFLHY 60
RTSKVRALRA ARLERLVHEL VSGDREQDPG FVPAFLATHR AFVPTARVLG FLLPPPPPPP 120
PPPAGVDSKR TEGQDLNFSK NLRAVVSVLG SWLRNHPQDF RDPPDHQNLG NVRIFLGWAA 180
PGGAEAREAE KLLEDFLKEA KGEQTEEEKR LAWSGPPRIA QTPGSEFAED CVEEEGPSSE 240
GPELLDFSVD DVAEQLTLMD VELFLRVRSC ECLGSMWSQR DRPGAAGISP TVRATVAQFN 300
TVTGCVLGSV LAAPGLAASQ RAQRIEKWIR IAQRCRELRN FSSLRAILSA LQSNPIYRLK 360
RSWGAVSREP LSVFRKLSQI FSDEDNHLSS RAILSQEETT EDDDCPSGSL PSKLPPGPVP 420
YLGTFLTDLV MLDTALPDTL KGNLINFEKR RKEWEILARI QQLQQRCQRY SLSPRPPILA 480
ALRAQRQLSE EQSYRVSRVI EPPAASCPSS PRIRRRISLT KRLSAKLSRE KNSSPGGSPG 540
DPSSPTSSVS PGSPPSSPRN REPPPPGSPP ASPGPQSPST KLSLTMDPPG PWPVTLTPSS 600
SRVPLLGQQT SEARVIRVSI NNNHGNLYRS ILLTCQDKAP SVVQRALEKH NVPQPWARDY 660
QLFQVLPGDR ELLIPDGANV FYAMSPAAPG DFLLRRKEGT GHTLSASPT 709 |
Gene Ontology | GO:0005622; C:intracellular; IEA:InterPro. GO:0008321; F:Ral guanyl-nucleotide exchange factor activity; IDA:MGI. GO:0017016; F:Ras GTPase binding; IDA:MGI. GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. GO:0007264; P:small GTPase mediated signal transduction; TAS:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |