CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003817
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytochrome P450 2D1 
Protein Synonyms/Alias
 CYPIID1; Cytochrome P450-CMF1A; Cytochrome P450-DB1; Cytochrome P450-UT-7; Debrisoquine 4-hydroxylase 
Gene Name
 Cyp2d1 
Gene Synonyms/Alias
 Cyp2d-1; Cyp2d9 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
284AFLAEVEKAKGNPESacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. 
Sequence Annotation
 METAL 446 446 Iron (heme axial ligand).  
Keyword
 Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 504 AA 
Protein Sequence
MELLNGTGLW SMAIFTVIFI LLVDLMHRRH RWTSRYPPGP VPWPVLGNLL QVDLSNMPYS 60
LYKLQHRYGD VFSLQKGWKP MVIVNRLKAV QEVLVTHGED TADRPPVPIF KCLGVKPRSQ 120
GVILASYGPE WREQRRFSVS TLRTFGMGKK SLEEWVTKEA GHLCDAFTAQ AGQSINPKAM 180
LNKALCNVIA SLIFARRFEY EDPYLIRMVK LVEESLTEVS GFIPEVLNTF PALLRIPGLA 240
DKVFQGQKTF MALLDNLLAE NRTTWDPAQP PRNLTDAFLA EVEKAKGNPE SSFNDENLRM 300
VVVDLFTAGM VTTATTLTWA LLLMILYPDV QRRVQQEIDE VIGQVRCPEM TDQAHMPYTN 360
AVIHEVQRFG DIAPLNLPRF TSCDIEVQDF VIPKGTTLII NLSSVLKDET VWEKPHRFHP 420
EHFLDAQGNF VKHEAFMPFS AGRRACLGEP LARMELFLFF TCLLQRFSFS VPVGQPRPST 480
HGFFAFPVAP LPYQLCAVVR EQGL 504 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0070330; F:aromatase activity; IEA:EC.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0004497; F:monooxygenase activity; IDA:RGD.
 GO:0042493; P:response to drug; IDA:RGD.
 GO:0014070; P:response to organic cyclic compound; IEP:RGD. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I.
 IPR008069; Cyt_P450_E_grp-I_CYP2D-like. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00463; EP450I.
 PR01686; EP450ICYP2D.
 PR00385; P450.