CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008394
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Methyl-CpG-binding protein 2 
Protein Synonyms/Alias
 MeCp-2 protein; MeCp2 
Gene Name
 MECP2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
142YLINPQGKAFRSKVEubiquitination[1]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. 
Sequence Annotation
 DOMAIN 90 162 MBD.
 DNA_BIND 185 197 A.T hook 1.
 DNA_BIND 265 277 A.T hook 2.
 MOD_RES 80 80 Phosphoserine.
 MOD_RES 116 116 Phosphoserine.
 MOD_RES 216 216 Phosphoserine.
 MOD_RES 229 229 Phosphoserine (By similarity).
 MOD_RES 423 423 Phosphoserine (By similarity).
 MOD_RES 426 426 Phosphoserine.
 MOD_RES 449 449 N6-acetyllysine.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Chromosomal rearrangement; Complete proteome; Disease mutation; DNA-binding; Mental retardation; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 486 AA 
Protein Sequence
MAAAAAAAPS GGGGGGEEER LEEKSEDQDL QGLKDKPLKF KKVKKDKKEE KEGKHEPVQP 60
SAHHSAEPAE AGKAETSEGS GSAPAVPEAS ASPKQRRSII RDRGPMYDDP TLPEGWTRKL 120
KQRKSGRSAG KYDVYLINPQ GKAFRSKVEL IAYFEKVGDT SLDPNDFDFT VTGRGSPSRR 180
EQKPPKKPKS PKAPGTGRGR GRPKGSGTTR PKAATSEGVQ VKRVLEKSPG KLLVKMPFQT 240
SPGGKAEGGG ATTSTQVMVI KRPGRKRKAE ADPQAIPKKR GRKPGSVVAA AAAEAKKKAV 300
KESSIRSVQE TVLPIKKRKT RETVSIEVKE VVKPLLVSTL GEKSGKGLKT CKSPGRKSKE 360
SSPKGRSSSA SSPPKKEHHH HHHHSESPKA PVPLLPPLPP PPPEPESSED PTSPPEPQDL 420
SSSVCKEEKM PRGGSLESDG CPKEPAKTQP AVATAATAAE KYKHRGEGER KDIVSSSMPR 480
PNREEPVDSR TPVTERVS 498 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0000792; C:heterochromatin; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0010385; F:double-stranded methylated DNA binding; IMP:MGI.
 GO:0003729; F:mRNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0035197; F:siRNA binding; IEA:Compara.
 GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
 GO:0008344; P:adult locomotory behavior; IEA:Compara.
 GO:0001662; P:behavioral fear response; IEA:Compara.
 GO:0032048; P:cardiolipin metabolic process; IEA:Compara.
 GO:0050432; P:catecholamine secretion; IEA:Compara.
 GO:0021549; P:cerebellum development; IEA:Compara.
 GO:0006342; P:chromatin silencing; IEA:Compara.
 GO:0016358; P:dendrite development; IEA:Compara.
 GO:0009790; P:embryo development; IEA:Compara.
 GO:0008211; P:glucocorticoid metabolic process; IEA:Compara.
 GO:0006541; P:glutamine metabolic process; IEA:Compara.
 GO:0016573; P:histone acetylation; IEA:Compara.
 GO:0016571; P:histone methylation; IEA:Compara.
 GO:0006020; P:inositol metabolic process; IEA:Compara.
 GO:0007616; P:long-term memory; IEA:Compara.
 GO:0060291; P:long-term synaptic potentiation; IEA:Compara.
 GO:0006122; P:mitochondrial electron transport, ubiquinol to cytochrome c; IEA:Compara.
 GO:0035067; P:negative regulation of histone acetylation; IEA:Compara.
 GO:0031061; P:negative regulation of histone methylation; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0001976; P:neurological system process involved in regulation of systemic arterial blood pressure; IEA:Compara.
 GO:0042551; P:neuron maturation; IEA:Compara.
 GO:0009405; P:pathogenesis; IEA:Compara.
 GO:0046470; P:phosphatidylcholine metabolic process; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0051965; P:positive regulation of synapse assembly; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0019230; P:proprioception; IEA:Compara.
 GO:0008104; P:protein localization; IEA:Compara.
 GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IEA:Compara.
 GO:0006349; P:regulation of gene expression by genetic imprinting; IEA:Compara.
 GO:0002087; P:regulation of respiratory gaseous exchange by neurological system process; IEA:Compara.
 GO:0007585; P:respiratory gaseous exchange; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0019233; P:sensory perception of pain; IEA:Compara.
 GO:0035176; P:social behavior; IEA:Compara.
 GO:0001964; P:startle response; IEA:Compara.
 GO:0007416; P:synapse assembly; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0021591; P:ventricular system development; IEA:Compara.
 GO:0008542; P:visual learning; IEA:Compara. 
Interpro
 IPR017956; AT_hook_DNA-bd_motif.
 IPR016177; DNA-bd_integrase-typ.
 IPR017353; Me_CpG-bd_MeCP2.
 IPR001739; Methyl_CpG_DNA-bd. 
Pfam
 PF01429; MBD 
SMART
 SM00384; AT_hook
 SM00391; MBD 
PROSITE
 PS50982; MBD 
PRINTS