UniProt Accession

 EFNA4_HUMAN; P52798; C9JHJ8; G3XAK2; O95457; Q5SR71; Q6FI57 

Genbank Protein ID

 U14188; AJ006352; AJ006353; CR533569; AL691442; CH471121; CH471121; BC107483 

Genbank Nucleotide ID

 AAC50079.1; CAA06992.1; CAA06993.1; CAG38600.1; EAW53138.1; EAW53139.1; AAI07484.1 

Protein Name

 Ephrin-A4 

Protein Synonyms/Alias

 EPH-related receptor tyrosine kinase ligand 4; LERK-4 

Gene Name

 EFNA4 

Gene Synonyms/Alias

 EPLG4; LERK4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
111	GHVQFSEKIQRFTPF	ubiquitination	[1]
154	LQVSVCCKERKSESA	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils. 

Sequence Annotation

 DOMAIN 26 155 Ephrin RBD.
 LIPID 170 170 GPI-anchor amidated serine (Potential).
 CARBOHYD 33 33 N-linked (GlcNAc...) (Potential).
 DISULFID 58 99 By similarity.
 DISULFID 86 144 By similarity.  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 201 AA 

Protein Sequence

Gene Ontology

 GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005005; F:transmembrane-ephrin receptor activity; TAS:ProtInc.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc. 

Interpro

 IPR008972; Cupredoxin.
 IPR001799; Ephrin.
 IPR019765; Ephrin_CS. 

Pfam

 PF00812; Ephrin 

SMART

  

PROSITE

 PS01299; EPHRIN_RBD_1
 PS51551; EPHRIN_RBD_2 

PRINTS

 PR01347; EPHRIN.