CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010018
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 DNA polymerase III PolC-type 
Protein Synonyms/Alias
 PolIII 
Gene Name
 polC 
Gene Synonyms/Alias
 MPN_034; MP120 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
197VKSMKVSKYDKQFETacetylation[1]
1411FSSLDDFKKRTKITKacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity). 
Sequence Annotation
 DOMAIN 408 567 Exonuclease.  
Keyword
 Complete proteome; Cytoplasm; DNA replication; DNA-directed DNA polymerase; Exonuclease; Hydrolase; Nuclease; Nucleotidyltransferase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1443 AA 
Protein Sequence
MVFDTETEKG KRIWALSQFL VKKNILDHNE LHQLNNRIEL VYLENDRENA LFLVALTLKK 60
PLTIDIWNAL YEGFQDAEGA ELRITFQEDA TFFKDGSTKS SVTLAIIKDY FKSFFGKDKK 120
YRILLEQELT HPNFLSYSNH ELKANCQSQE LDQWLIEQRQ AFIKWMHQAG FTHFGFVSLF 180
NPPAEKQLKV KSMKVSKYDK QFETEVFSTE FVPIHKINQQ MDEIKLMGQI FELKDFPGYN 240
NLRNTLNIYV TDFQLGGSLI LKWFYKDPKT IEGIKIGTWV KATVKVERDA KTQLLQGIIK 300
EISPIETPAY YRRPDQDKQK RVELVFHTKM SAFDGINSVQ EYAQFAKERD WKTIAVTDKD 360
NIHIYPTLYE VAKKYGLKAI YGLECNLIDD HIKIVSNPDK TKLKDATFVI FDIETTGLHG 420
RYDSVIEFAG IKVKHNREVE RMQFFLKIDG PLPAAVTEIT KITQAQLEDG MEQQAGLEKL 480
RAWLDGCVMV AHNGLSFDLP FLQTQFEKYN IAPLTNPLID TLALSWALNP GFASHTLSNI 540
CAKLKFDFDD ERLHRADYDT QALKKVFDYF KEQVELMGIT NLEQLDQELN QQCHFELLKR 600
TFTNTGIIYI KSQSGFAKLY ELLSIALTDN NATRPLVLTS TLQKFAKSFV ITDNPVQGDI 660
FKAALTKPLK ELEAAIKRVD FVLIAPPGAY AGYTIREGLK KEAIPNAIKL VVDTAQRLNK 720
LVAVASDAYF IHPWENEYYK AIVCAKGLGG RWHRHFNYKE REQRVPNVFV RTTGEMLNEM 780
SFLGEQLAYE LVVENTNKLA KQLTADDLVP VQTKLQPPVI EGSNENLAAK TWSQAKAIYG 840
DPLPKLIEQR IQEELKAIID NGFGIIYWIS HLLVKQSVQD GYFVGPRGSI GSSLVANLIG 900
ISEINPLVPH YLCESCQYFE VNEEVDDGYD LMVRDCPKCG AKAAFKGDGH NIPFATFMGF 960
AGDKIPDIDL NFSSEYQAKA HAYVRELFGE QYTFRAGTIA TVAEKTAYGY ARNYFEIIKQ 1020
TELATAPEIE RFKQKLVGIK RTTGQHPGGI MIFPNHKSVY EFTPCGYPAD DTSSDWKTTH 1080
FEYDALGNTI LKLDILGQDD PTMLKHLGDL THVNPQNIPR FDKKLTEMFW SVNPLKLKPH 1140
YLDEPTGAIG IPEFGTKFVR KILEQTKPKG FGDLIRVSGL SHGKNVWADN AQKILKDQNL 1200
SLKDVIACRD DIMLYLIHKG MQAKDAFEIM EKVRKGIALN AKEVQLMQSN GVEQHWINSC 1260
LKISYLFPKA HAAAYVLMAW RIAWFKLYHP LSYYACLLSF KLKEHDVSGF KSGVSFVKQK 1320
LEELNTLYRI KRIKPKEAEL LTSYEVYLEM MARGIKLEQI SLTHSHATRF VEHNGMLIAP 1380
FITIPGMGEA VANSIIEARN EKPFSSLDDF KKRTKITKKH IEAFTQMQLL DEFREQDNQK 1440
KLF 1443 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC. 
Interpro
 IPR011708; DNA_pol3_alpha.
 IPR006054; DnaQ.
 IPR006055; Exonuclease.
 IPR013520; Exonuclease_RNaseT/DNA_pol3.
 IPR004013; PHP_C.
 IPR003141; Pol/His_phosphatase_N.
 IPR006308; PolC_gram_pos.
 IPR012337; RNaseH-like_dom. 
Pfam
 PF07733; DNA_pol3_alpha
 PF02811; PHP
 PF00929; RNase_T 
SMART
 SM00479; EXOIII
 SM00481; POLIIIAc 
PROSITE
  
PRINTS