CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033876
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Translationally-controlled tumor protein 
Protein Synonyms/Alias
  
Gene Name
 Tpt1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
59EAYKKYIKDYMKSLKacetylation[1]
63KYIKDYMKSLKGKLEacetylation[1]
68YMKSLKGKLEEQKPEacetylation[1]
73KGKLEEQKPERVKPFacetylation[1, 2]
78EQKPERVKPFMTGAAacetylation[1, 2, 3]
78EQKPERVKPFMTGAAsuccinylation[2]
78EQKPERVKPFMTGAAubiquitination[4]
130TPFMIFFKDGLEMEKubiquitination[4]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 138 AA 
Protein Sequence
MVSRTEGAID DSLIGGNASA EGPEGEGTES TVVTGVDIVM NHHLQETSFT KEAYKKYIKD 60
YMKSLKGKLE EQKPERVKPF MTGAAEQIKH ILANFNNYQF FIGENMNPDG MVALLDYRED 120
GVTPFMIFFK DGLEMEKC 138 
Gene Ontology
 GO:0005615; C:extracellular space; ISO:MGI.
 GO:0005771; C:multivesicular body; ISO:MGI.
 GO:0045298; C:tubulin complex; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
 GO:0009615; P:response to virus; IEA:Compara. 
Interpro
 IPR011057; Mss4-like.
 IPR011323; Mss4/transl-control_tumor.
 IPR018103; Translation_control_tumour_CS.
 IPR018105; Translational_control_tumour_p. 
Pfam
 PF00838; TCTP 
SMART
  
PROSITE
 PS01002; TCTP_1
 PS01003; TCTP_2 
PRINTS
 PR01653; TCTPROTEIN.