CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015246
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Round spermatid basic protein 1-like protein 
Protein Synonyms/Alias
  
Gene Name
 RSBN1L 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
28SEKEPFGKLQLSSRDacetylation[1]
191REENGEVKPLPRDKIacetylation[2]
329EFPFVSLKEPRVQNNacetylation[3]
506WGTLSSLKLQSRKDSubiquitination[4]
548KRTTNEIKNLQYLPRubiquitination[4, 5, 6, 7]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [7] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 28 28 N6-acetyllysine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 846 AA 
Protein Sequence
MAEPPSPVHC VAAAAPTATV SEKEPFGKLQ LSSRDPPGSL SAKKVRTEEK KAPRRVNGEG 60
GSGGNSRQLQ PPAAPSPQSY GSPASWSFAP LSAAPSPSSS RSSFSFSAGT AVPSSASASL 120
SQPVPRKLLV PPTLLHAQPH HLLLPAAAAA ASANAKSRRP KEKREKERRR HGLGGAREAG 180
GASREENGEV KPLPRDKIKD KIKERDKEKE REKKKHKVMN EIKKENGEVK ILLKSGKEKP 240
KTNIEDLQIK KVKKKKKKKH KENEKRKRPK MYSKSIQTIC SGLLTDVEDQ AAKGILNDNI 300
KDYVGKNLDT KNYDSKIPEN SEFPFVSLKE PRVQNNLKRL DTLEFKQLIH IEHQPNGGAS 360
VIHAYSNELS HLSPMEMERF AEEFVGLVFS ENENSAAFYV MGIVHGAATY LPDFLDYFSF 420
NFPNSPVKME ILGKKDIETT TMSNFHAQVK RTYSHGTYRA GPMRQISLVG AVDEEVGDYF 480
PEFLDMLEES PFLKCTLPWG TLSSLKLQSR KDSDDGPIMW VRPGEQMIPV ADMPKSPFKR 540
KRTTNEIKNL QYLPRTSEPR EMLFEDRTRA HADHIGQGFE RQTTAAVGVL KAVHCGEWPD 600
QPRITKDVIC FHAEDFLEVV QRMQLDLHEP PLSQCVQWVD DAKLNQLRRE GIRYARIQLY 660
DNDIYFIPRN VVHQFKTVSA VCSLAWHIRL KLYHSEEDTS QNTATHETGT SSDSTSSVLG 720
PHTDNMICAV SKASLDSVFS DKLHSKYELQ QIKHEPIASV RIKEEPVNVN IPEKTTALNN 780
MDGKNVKAKL DHVQFAEFKI DMDSKFENSN KDLKEELCPG NLSLVDTRQH SSAHSNQDKK 840
DDDILC 846 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. 
Interpro
 IPR026306; RSBN1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS