CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039714
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Denticleless protein homolog 
Protein Synonyms/Alias
  
Gene Name
 DTL 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
81AAGDQTAKFWDVKAGubiquitination[1, 2, 3]
86TAKFWDVKAGELIGTubiquitination[2, 3, 4, 5]
95GELIGTCKGHQCSLKubiquitination[3, 4, 5]
102KGHQCSLKSVAFSKFubiquitination[3, 4, 5]
108LKSVAFSKFEKAVFCubiquitination[2, 3]
111VAFSKFEKAVFCTGGubiquitination[3, 5]
152GAHNTSDKQTPSKPKubiquitination[3, 4]
159KQTPSKPKKKQNSKGubiquitination[3]
205IKVWDLRKNYTAYRQubiquitination[3]
218RQEPIASKSFLYPGSubiquitination[1, 2, 3, 4, 5, 6]
333WCPSDFTKIATCSDDubiquitination[4]
344CSDDNTLKIWRLNRGubiquitination[2, 3, 4, 5]
355LNRGLEEKPGGDKLSubiquitination[3]
360EEKPGGDKLSTVGWAubiquitination[3, 4, 5]
390SSQSTPAKAPRAKCNubiquitination[1, 6]
487TKIMSPRKALIPVSQubiquitination[4]
495ALIPVSQKSSQAEACubiquitination[4]
522SSCLESVKQKCVKSCubiquitination[3]
666ITPSSMRKICTYFHRubiquitination[3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 688 AA 
Protein Sequence
MLFNSVLRQP QLGVLRNAPN MEHVLAVANE EGFVRLYNTE SQSFRKKCFK EWMAHWNAVF 60
DLAWVPGELK LVTAAGDQTA KFWDVKAGEL IGTCKGHQCS LKSVAFSKFE KAVFCTGGRD 120
GNIMVWDTRC NKKDGFYRQV NQISGAHNTS DKQTPSKPKK KQNSKGLAPS VDFQQSVTVV 180
LFQDENTLVS AGAVDGIIKV WDLRKNYTAY RQEPIASKSF LYPGSSTRKL GYSSLILDST 240
GSTLFANCTD DNIYMFNMTG LKTSPVAIFN GHQNSTFYVK SSLSPDDQFL VSGSSDEAAY 300
IWKVSTPWQP PTVLLGHSQE VTSVCWCPSD FTKIATCSDD NTLKIWRLNR GLEEKPGGDK 360
LSTVGWASQK KKESRPGLVT VTSSQSTPAK APRAKCNPSN SSPSSAACAP SCAGDLPLPS 420
NTPTFSIKTS PAKARSPINR RGSVSSVSPK PPSSFKMSIR NWVTRTPSSS PPITPPASET 480
KIMSPRKALI PVSQKSSQAE ACSESRNRVK RRLDSSCLES VKQKCVKSCN CVTELDGQVE 540
NLHLDLCCLA GNQEDLSKDS LGPTKSSKIE GAGTSISEPP SPISPYASES CGTLPLPLRP 600
CGEGSEMVGK ENSSPENKNW LLAMAAKRKA ENPSPRSPSS QTPNSRRQSG KKLPSPVTIT 660
PSSMRKICTY FHRKSQEDFC GPEHSTEL 688 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA. 
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS