CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036327
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 cAMP-specific 3',5'-cyclic phosphodiesterase 4D 
Protein Synonyms/Alias
  
Gene Name
 PDE4D 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
85SIPRFGVKTEQEDVLubiquitination[1]
284MNLLADLKTMVETKKubiquitination[1]
324ADLSNPTKPLQLYRQubiquitination[1]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Metal-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 422 AA 
Protein Sequence
MASNKFKRML NRELTHLSEM SRSGNQVSEF ISNTFLDKQH EVEIPSPTQK EKEKKKRPMS 60
QISGVKKLMH SSSLTNSSIP RFGVKTEQED VLAKELEDVN KWGLHVFRIA ELSGNRPLTV 120
IMHTIFQERD LLKTFKIPVD TLITYLMTLE DHYHADVAYH NNIHAADVVQ STHVLLSTPA 180
LEAVFTDLEI LAAIFASAIH DVDHPGVSNQ FLINTNSELA LMYNDSSVLE NHHLAVGFKL 240
LQEENCDIFQ NLTKKQRQSL RKMVIDIVLA TDMSKHMNLL ADLKTMVETK KVTSSGVLLL 300
DNYSDRIQVL QNMVHCADLS NPTKPLQLYR QWTDRIMEEF FRQGDRERER GMEISPMCDK 360
HNASVEKSQV GFIDYIVHPL WETWADLVHP DAQDILDTLE DNREWYQSTI PQSPSPAPDD 420
PE 422 
Gene Ontology
 GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0007568; P:aging; IEA:Compara.
 GO:0071222; P:cellular response to lipopolysaccharide; IEA:Compara.
 GO:0008152; P:metabolic process; IEA:GOC.
 GO:0035264; P:multicellular organism growth; IEA:Compara.
 GO:0030593; P:neutrophil chemotaxis; IEA:Compara.
 GO:0007165; P:signal transduction; IEA:InterPro.
 GO:0006939; P:smooth muscle contraction; IEA:Compara. 
Interpro
 IPR003607; HD/PDEase_dom.
 IPR023088; PDEase.
 IPR002073; PDEase_catalytic_dom.
 IPR023174; PDEase_CS. 
Pfam
 PF00233; PDEase_I 
SMART
 SM00471; HDc 
PROSITE
 PS00126; PDEASE_I 
PRINTS
 PR00387; PDIESTERASE1.