UniProt Accession

 SEC11_YEAST; P15367; D6VVV3 

Genbank Protein ID

 X07694; Z38061; AY558239; BK006942 

Genbank Nucleotide ID

 CAA30533.1; CAA86182.1; AAS56565.1; DAA08569.1 

Protein Name

 Signal peptidase complex catalytic subunit SEC11 

Protein Synonyms/Alias

 Secretory protein 11; Signal peptidase I 

Gene Name

 SEC11 

Gene Synonyms/Alias

 YIR022W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
77	VVYEVEGKQIPIVHR	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Catalytic component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum. 

Sequence Annotation

 ACT_SITE 44 44 By similarity.
 CARBOHYD 121 121 N-linked (GlcNAc...) (Potential).  

Keyword

 Complete proteome; Endoplasmic reticulum; Glycoprotein; Hydrolase; Membrane; Protease; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 167 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005787; C:signal peptidase complex; IDA:SGD.
 GO:0008233; F:peptidase activity; IMP:SGD.
 GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
 GO:0045047; P:protein targeting to ER; IMP:SGD.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0006465; P:signal peptide processing; IMP:SGD. 

Interpro

 IPR019758; Pept_S26A_signal_pept_1_CS.
 IPR019756; Pept_S26A_signal_pept_1_Ser-AS.
 IPR019759; Peptidase_S24_S26.
 IPR015927; Peptidase_S24_S26A/B/C.
 IPR001733; Peptidase_S26B.
 IPR027245; Sec11-like. 

Pfam

 PF00717; Peptidase_S24 

SMART

  

PROSITE

 PS00501; SPASE_I_1
 PS00761; SPASE_I_3 

PRINTS

 PR00728; SIGNALPTASE.