CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044677
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serine/threonine-protein kinase SMG1 
Protein Synonyms/Alias
  
Gene Name
 Smg1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
642LLGILLKKDNLNQDTacetylation[1]
1209PDPRELQKSIEVQLLubiquitination[2]
1554WAYRWGRKVVDNASQubiquitination[2]
3355HLLKAMAKDEEAALAubiquitination[2]
Reference
 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3582 AA 
Protein Sequence
MRFLRTDSAS ADPDTLKYSS SRDRGVSSSY GLQPSNSAVV SRQRHDDTRG HADIQNDEKE 60
RSMSYSDESR LSNLLRRITR EDDRDRRLAT VKQLKEFIQQ PENKLVLVKQ LDNILAAVHD 120
VLNESSKLLQ ELRQEGACCL GLLCASLSYE AEKIFKWIFS KFSSSAKDEV KLLYLCATYR 180
ALETVGEKKA FSSVMQLVMT SLQSILENVD TPELLCKCVK CILLVARCYP HIFSTNFRDT 240
VDILVGWHID HTQKPSLTQQ VSGWLQSLEP FWVADLAFST TLLGQFLEDM EAYAEDLSHV 300
ASGESVDEDV PPPSVSLPKL AALLRVFSTV VRSIGERFSP IRGPPITEAY VTDVLYRVMR 360
CVTAANQVFF SEAVLTAANE CVGVLLGSLD PSMTIHCDMV ITYGLDQLEN CQTCGTDYII 420
SVLNLLTLIV EQINTKLPSS FVEKLFIPSS KLLFLRYHKE KEVVAVAHAV YQAVLSLKNI 480
PVLETAYKLI LGEMTCALNN LLHSLQLPDA CSEIKHEAFQ NHVFNIDNAN FVVIFDLSAL 540
TTIGNAKNSL IGMWALSPTV FALLSKNLMI VHSDLAVHFP AIQYAVLYTL YSHCTRHDHF 600
ISSSLSSSSP SLFDGAVIST VTTATKKHFS IILNLLGILL KKDNLNQDTR KLLMTWALEV 660
AVLMKKSETY APLFSLPSFH KFSKGLLANT LVEDVNICLQ ACSSLHALSS SLPDDLLQRC 720
VDVCRVQLVH SGTRIRQAFG KLLKSIPLDV VLSNNNHTEI QEISLALRSH MSKAPSNTFH 780
PQDFSDVISF ILYGNSHRTG KDNWLERLFY SCQRLDKRDQ STIPRNLLKT DAVLWQWAIW 840
EAAQFTVLSK LRTPLGRAQD TFQTIEGIIR SLAAHTLNPD QDVSQWTTAD NDEGHGSNQL 900
RLVLLLQYLE NLEKLMYNAY EGCANALTSP PKVIRTFFYT NRQTCQDWLT RIRLSIMRVG 960
LLAGQPAVTV RHGFDLLTEM KTNSLTQGSE LEVTIMMVVE ALCELHCPEA IQGIAVWSSS 1020
AVGKNLLWIN SVAQQAEGRF EKASVEYQEH LCAMTGVDCC ISSFDKSVLT LANAGRNSAS 1080
PKHSLNGESR KTVLSKSIDS SPEVISYLGN KACECYISIA DWAAVQEWQN AVHDLKKNSS 1140
STSLNLKADF NYIKSLSSFE SGEFVECTEQ LELLPGENIN LLAGGSKEKI DMKKLLPNML 1200
SPDPRELQKS IEVQLLRSSV FLATALNHME QDQKWQSLTE NVVKYLKQTS RIAIGPLRLS 1260
TLTVSQSLPV LSTLQLYCSS ALENTVSNRL STEDCLIPLF SDALRSCKQH DVRPWMQALR 1320
YTMYQNQLLE KIKEQTVPIR SHLMELGLTA AKFARKRGNV SLATRLLAQC SEVQLGKTTT 1380
AQDLVQHFKK LSTQGQVDEK WGPELDIEKT KLLYTAGQST HAMEMLSSCA ISFCKSAKAE 1440
YAVAKSILTL AKWVQAEWKE ISGQLRQVYR AQQQQNLSGL STLSRNILAL IELPSANTVG 1500
EEHPRIESES TVHIGVGEPD FILGQLYHLS SVQAPEVAKS WAALASWAYR WGRKVVDNAS 1560
QGEGVRLLPR EKSEVQNLLP DTITEEEKER IYGILGQAVC RPAGIQDEDI TLQITESEDN 1620
EDDDMVDVIW RQLISSCPWL SELDENATEG VIKVWRKVVD RIFSLYKLSC SAYFTFLKLN 1680
AGQVLLDEDD PRLHLSHRAE QSTDDVIVMA TLRLLRLLVK HAGELRQYLE HGLETTPTAP 1740
WRGIIPQLFS RLNHPEVYVR QSICNLLCRV AQDSPHLILY PAIVGTISLS SESQASGNKY 1800
SSAIPTLLGN IQGEELLVSE CEGGSPPASQ DSNKDEPKSG LNEDQAMMQD CYSKIVDKLS 1860
SANPTMVLQV QMLVAELRRV TVLWDELWLG VLLQQHMYVL RRIQQLEDEV KRVQNNNTLR 1920
KEEKIAIMRE KHTALMKPIV FALEHVRSIT AAPAETPHEK WFQDNYGDAI DNALEKLKTP 1980
SNPAKPGSSW IPFKEIMLSL QQRAQKRASY ILRLDEISPW LAAMTNTEIA LPGEVSARDT 2040
VTIHSVGGTI TILPTKTKPK KLLFLGSDGK SYPYLFKGLE DLHLDERIMQ FLSIVNTMFA 2100
TINRQETPRF HARHYSVTPL GTRSGLIQWV DGATPLFGLY KRWQQREAAL QAQKAQDSYQ 2160
TPQNPSIVPR PSELYYSKIG PALKTVGLSL DVSRRDWPLH VMKAVLEELM EATPPNLLAK 2220
ELWSSCTTPD EWWRVTQSYA RSTAVMSMVG YIIGLGDRHL DNVLIDMTTG EVVHIDYNVC 2280
FEKGKSLRVP EKVPFRMTQN IETALGVTGV EGVFRLSCEQ VLHIMRRGRE TLLTLLEAFV 2340
YDPLVDWTAG GEAGFAGAVY GGGGQQAESK QSKREMEREI TRSLFSSRVA EIKVNWFKNR 2400
DEMLVVLPKL DSSLDEYLSL QEQLTDVEKL QGKLLEEIEF LEGAEGVDHP SHTLQHRYSE 2460
HTQLQTQQRA VQEAIQVKLN EFEQWITHYQ AAFNNLEATQ LASLLQEIST QMDLGPPSYV 2520
PATAFLQNAG QAHLISQCEQ LEGEVGALLQ QRRSVLRGCL EQLHHYATVA LQYPKAIFQK 2580
HRIEQWKAWM EELICNTTVE RCQELYRKYE MQYAPQPPPT VCQFITATEM TLQRYAADIN 2640
SRLIRQVERL KQEAVTVPVC EDQLKEIERC IKVFLHENGE EGSLSLASVI ISALCTLTRR 2700
NLMMEGAASS AGEQLVDLTS RDGAWFLEEL CSMSGNVTCL VQLLKQCHLV PQDLDIPNPV 2760
EASEAVHLAN GVYTSLQELN SNFRQIIFPE ALRCLMKGEC TLESMLHELD SLIEQTTDGV 2820
PLQTLVESLQ AYLRNTAMGL EEETHAHYID VARMLHAQYG ELIQPRNGSV DETPKMSAGQ 2880
MLLVAFDGMF AQVETAFGLL VEKLNKMEIP VAWRKIDIIR EARSTQVNFF DDDNHRQVLE 2940
EIFFLKRLQT IKEFFRLCGT FSKTLSGSSS LEDQNTVNGP VQIVNVKTLF RNSCFSEDQM 3000
AKPIKAFTAD FVRQLLIGLP NQALGLTLCS FISALGVDII AQVEAKDFGA ESKVSVDDLC 3060
KKAVEHNIQV GKFSQLVMNR ATVLASSYDT AWKKHDLVRR LETSISSCKT SLQRVQLHIA 3120
MFQWQHEDLL ISRPQAMSVT PPRSAILTSM KKKLHALSQI ETSIGTVQEK LAALEASIEQ 3180
RLKWAGGANP ALAPVLQDFE ATIAERRNLV LKESQRANQV TFLCSNIIHF ESLRTRTAEA 3240
LSLDAALFEL IKRCQQMCSF ASQFNSSVSE LELRLLQRVD TTLEHPIGSS EWLLSAHKQL 3300
TQDMSTQRAV QTEKEQQIET VCETIQSLVD SVKTVLTGHN RQLGDVKHLL KAMAKDEEAA 3360
LADAEDIPYE SSVRQFLAEY KSWQDNIQTV LFTLVQAMGQ VRSQEHVEML QEITPTLKEL 3420
KTQSQSIYNN LVSFASPLVT DAANECSSPT SSATYQPSFA AAVRSNTGQK TQPDVMSQNA 3480
KKLIQKNLAT SADTPPSTIP GTGKSIACSP KKAVRDPKTG KAVQERNSYA VSVWKRVKAK 3540
LEGRDVDPNR RMSVAEQVDY VIKEATNLDN LAQLYEGWTA WV 3582 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR003152; FATC.
 IPR011009; Kinase-like_dom.
 IPR000403; PI3/4_kinase_cat_dom.
 IPR018936; PI3/4_kinase_CS.
 IPR014009; PIK_FAT. 
Pfam
 PF02260; FATC
 PF00454; PI3_PI4_kinase 
SMART
 SM00146; PI3Kc 
PROSITE
 PS51189; FAT
 PS51190; FATC
 PS00916; PI3_4_KINASE_2
 PS50290; PI3_4_KINASE_3 
PRINTS