CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030803
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 MKL/myocardin-like 2, isoform CRA_a 
Protein Synonyms/Alias
 MKL/myocardin-like protein 2; MKL2 protein; cDNA FLJ61243, highly similar to MKL/myocardin-like protein 2 
Gene Name
 MKL2 
Gene Synonyms/Alias
 hCG_1982625 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
157GPMELVEKNILPVDSacetylation[1]
360TILPAPFKPLNDKNSacetylation[1, 2, 3]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1099 AA 
Protein Sequence
MDHTGAIDTE DEVGPLAHLA PSPQSEAVAH EFQELSLQSS QNLPPLNERK NVLQLRLQQR 60
RTREQLVDQG IMPPLKSPAA FHEQIKSLER ARTENFLKHK IRSRPDRSEL VRMHILEETF 120
AEPSLQATQM KLKRARLADD LNEKIAQRPG PMELVEKNIL PVDSSVKEAI IGVGKEDYPH 180
TQGDFSFDED SSDALSPDQP ASQESQGSAA SPSEPKVSES PSPVTTNTPA QFASVSPTVP 240
EFLKTPPTAD QPPPRPAAPV LPTNTVSSAK PGPALVKQSH PKNPNDKHRS KKCKDPKPRV 300
KKLKYHQYIP PDQKGEKNEP QMDSNYARLL QQQQLFLQLQ ILSQQKQHYN YQTILPAPFK 360
PLNDKNSNSG NSALNNATPN TPRQNTSTPV RKPGPLPSSL DDLKVSELKT ELKLRGLPVS 420
GTKPDLIERL KPYQEVNSSG LAAGGIVAVS SSAIVTSNPE VTVALPVTTL HNTVTSSVST 480
LKAELPPTGT SNATRVENVH SPLPISPSPS EQSSLSTDDT NMADTFTEIM TMMSPSQFLS 540
SSPLRMTNNE DSLSPTSSTL SNLELDAAEK DRKLQEKEKQ IEELKRKLEQ EQKLVEVLKM 600
QLEVEKRGQQ QRPLEAQPSA PGHSVKSDQK HGSLGSSIKD EASLPDCSSS RQPIPVASHA 660
VGQPVSTGGQ TLVAKKAVVI KQEVPVGQAE QQSVVSQFYV SSQGQPPPAV VAQPQALLTT 720
QTAQLLLPVS IQGSSVTSVQ LPVGSLKLQT SPQAGMQTQP QIATAAQIPT AALASGLAPT 780
VPQTQDTFPQ HVLSQPQQVR KVFTNSASSN TVLPYQRHPA PAVQQPFINK ASNSVLQSRN 840
APLPSLQNGP NTPNKPSSPP PPQQFVVQHS LFGSPVAKTK DPPRYEEAIK QTRSTQAPLP 900
EISNAHSQQM DDLFDILIKS GEISLPIKEE PSPISKMRPV TASITTMPVN TVVSRPPPQV 960
QMAPPVSLEP MGSLSASLEN QLEAFLDGTL PSANEIPPLQ SSSEDREPFS LIEDLQNDLL 1020
SHSGMLDHSH SPMETSETQF AAGTPCLSLD LSDSNLDNME WLDITMPNSS SGLTPLSTTA 1080
PSMFSADFLD PQDLPLPWD 1099 
Gene Ontology
 GO:0003676; F:nucleic acid binding; IEA:InterPro. 
Interpro
 IPR004018; RPEL_repeat.
 IPR003034; SAP_dom. 
Pfam
 PF02755; RPEL
 PF02037; SAP 
SMART
 SM00707; RPEL
 SM00513; SAP 
PROSITE
 PS51073; RPEL
 PS50800; SAP 
PRINTS