CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004902
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytochrome P450 4A2 
Protein Synonyms/Alias
 CYPIVA2; Cytochrome P-450 K-2; Cytochrome P450 K-5; Cytochrome P450-LA-omega 2; Lauric acid omega-hydroxylase 
Gene Name
 Cyp4a2 
Gene Synonyms/Alias
 Cyp4a-2; Cyp4a11 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
493PRLVLKSKNGIHLRLacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. 
Sequence Annotation
 METAL 451 451 Iron (heme axial ligand).
 BINDING 315 315 Heme (covalent; via 1 link).  
Keyword
 Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 504 AA 
Protein Sequence
MGFSVFSPTR SLDGVSGFFQ GAFLLSLFLV LFKAVQFYLR RQWLLKALEK FPSTPSHWLW 60
GHNLKDREFQ QVLTWVEKFP GACLQWLSGS TARVLLYDPD YVKVVLGRSD PKPYQSLAPW 120
IGYGLLLLNG KKWFQHRRML TPAFHYDILK PYVKIMADSV SIMLDKWEKL DDQDHPLEIF 180
HYVSLMTLDT VMKCAFSHQG SVQLDVNSRS YTKAVEDLNN LIFFRVRSAF YGNSIIYNMS 240
SDGRLSRRAC QIAHEHTDGV IKTRKAQLQN EEELQKARKK RHLDFLDILL FAKMEDGKSL 300
SDEDLRAEVD TFMFEGHDTT ASGISWVFYA LATHPEHQER CREEVQSILG DGTSVTWDHL 360
DQMPYTTMCI KEALRLYSPV PSVSRELSSP VTFPDGRSIP KGIRVTILIY GLHHNPSYWP 420
NPKVFDPSRF SPDSPRHSHA YLPFSGGARN CIGKQFAMNE LKVAVALTLL RFELLPDPTR 480
IPVPMPRLVL KSKNGIHLRL KKLR 504 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD.
 GO:0018685; F:alkane 1-monooxygenase activity; IMP:RGD.
 GO:0008405; F:arachidonic acid 11,12-epoxygenase activity; TAS:RGD.
 GO:0050544; F:arachidonic acid binding; IDA:RGD.
 GO:0052869; F:arachidonic acid omega-hydroxylase activity; IEA:EC.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0019369; P:arachidonic acid metabolic process; IMP:RGD.
 GO:0046456; P:icosanoid biosynthetic process; IMP:RGD.
 GO:0001822; P:kidney development; IEP:RGD.
 GO:0048252; P:lauric acid metabolic process; IDA:RGD.
 GO:0043651; P:linoleic acid metabolic process; IDA:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0009725; P:response to hormone stimulus; IEP:RGD. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00463; EP450I.
 PR00385; P450.