CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009132
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Neurexin-1-beta 
Protein Synonyms/Alias
 Neurexin I-beta 
Gene Name
 NRXN1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
419QSNGAVVKEKQPSSAubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity). 
Sequence Annotation
 DOMAIN 91 259 Laminin G-like.
 METAL 141 141 Calcium.
 METAL 158 158 Calcium; via carbonyl oxygen.
 METAL 210 210 Calcium; via carbonyl oxygen.
 METAL 212 212 Calcium.
 CARBOHYD 188 188 N-linked (GlcNAc...) (Potential).  
Keyword
 3D-structure; Alternative promoter usage; Alternative splicing; Angiogenesis; Calcium; Cell adhesion; Cell junction; Cell membrane; Complete proteome; Glycoprotein; Membrane; Metal-binding; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 442 AA 
Protein Sequence
MYQRMLRCGA ELGSPGGGGG GGGGGGAGGR LALLWIVPLT LSGLLGVAWG ASSLGAHHIH 60
HFHGSSKHHS VPIAIYRSPA SLRGGHAGTT YIFSKGGGQI TYKWPPNDRP STRADRLAIG 120
FSTVQKEAVL VRVDSSSGLG DYLELHIHQG KIGVKFNVGT DDIAIEESNA IINDGKYHVV 180
RFTRSGGNAT LQVDSWPVIE RYPAGRQLTI FNSQATIIIG GKEQGQPFQG QLSGLYYNGL 240
KVLNMAAEND ANIAIVGNVR LVGEVPSSMT TESTATAMQS EMSTSIMETT TTLATSTARR 300
GKPPTKEPIS QTTDDILVAS AECPSDDEDI DPCEPSSGGL ANPTRAGGRE PYPGSAEVIR 360
ESSSTTGMVV GIVAAAALCI LILLYAMYKY RNRDEGSYHV DESRNYISNS AQSNGAVVKE 420
KQPSSAKSSN KNKKNKDKEY YV 442 
Gene Ontology
 GO:0044295; C:axonal growth cone; ISS:BHF-UCL.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0009986; C:cell surface; ISS:BHF-UCL.
 GO:0030139; C:endocytic vesicle; ISS:BHF-UCL.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0042734; C:presynaptic membrane; TAS:BHF-UCL.
 GO:0048306; F:calcium-dependent protein binding; ISS:BHF-UCL.
 GO:0050839; F:cell adhesion molecule binding; ISS:BHF-UCL.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0097109; F:neuroligin family protein binding; ISS:BHF-UCL.
 GO:0005102; F:receptor binding; ISS:BHF-UCL.
 GO:0001525; P:angiogenesis; ISS:UniProtKB.
 GO:0016339; P:calcium-dependent cell-cell adhesion; ISS:BHF-UCL.
 GO:0045184; P:establishment of protein localization; ISS:BHF-UCL.
 GO:0060325; P:face morphogenesis; IMP:BHF-UCL.
 GO:0097112; P:gamma-aminobutyric acid receptor clustering; ISS:BHF-UCL.
 GO:0097116; P:gephyrin clustering; ISS:BHF-UCL.
 GO:0097117; P:guanylate kinase-associated protein clustering; ISS:BHF-UCL.
 GO:0007157; P:heterophilic cell-cell adhesion; ISS:BHF-UCL.
 GO:0097114; P:N-methyl-D-aspartate receptor clustering; ISS:BHF-UCL.
 GO:0097118; P:neuroligin clustering; ISS:BHF-UCL.
 GO:0007158; P:neuron cell-cell adhesion; ISS:BHF-UCL.
 GO:0023041; P:neuronal signal transduction; TAS:BHF-UCL.
 GO:0043473; P:pigmentation; IMP:BHF-UCL.
 GO:0090004; P:positive regulation of establishment of protein localization to plasma membrane; ISS:BHF-UCL.
 GO:2000463; P:positive regulation of excitatory postsynaptic membrane potential; ISS:BHF-UCL.
 GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; ISS:BHF-UCL.
 GO:0097119; P:postsynaptic density protein 95 clustering; ISS:BHF-UCL.
 GO:0097104; P:postsynaptic membrane assembly; ISS:BHF-UCL.
 GO:0097105; P:presynaptic membrane assembly; ISS:BHF-UCL.
 GO:0097120; P:receptor localization to synapse; ISS:BHF-UCL.
 GO:2000311; P:regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; ISS:BHF-UCL.
 GO:2000310; P:regulation of N-methyl-D-aspartate selective glutamate receptor activity; ISS:BHF-UCL.
 GO:0035176; P:social behavior; IMP:BHF-UCL.
 GO:0097091; P:synaptic vesicle clustering; ISS:BHF-UCL. 
Interpro
 IPR008985; ConA-like_lec_gl_sf.
 IPR013320; ConA-like_subgrp.
 IPR001791; Laminin_G.
 IPR003585; Neurexin-like. 
Pfam
 PF02210; Laminin_G_2 
SMART
 SM00294; 4.1m
 SM00282; LamG 
PROSITE
 PS50025; LAM_G_DOMAIN 
PRINTS