CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033613
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Rotatin 
Protein Synonyms/Alias
  
Gene Name
 RTTN 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
171NQTVKCLKFSTFPWLubiquitination[1]
279DPGFFSNKHDTVSQNubiquitination[2]
617LLQGESQKVLLHMLSubiquitination[1]
767MLRLLLVKKPSVRSLubiquitination[1]
792SEEGADTKRPLIDARubiquitination[1]
811VTDLFIGKKPIELRLacetylation[3]
811VTDLFIGKKPIELRLubiquitination[1, 3]
812TDLFIGKKPIELRLDubiquitination[1]
849DVDLVLRKSAAEQLAubiquitination[1]
1107LNDRLSLKGCPGPCGubiquitination[1]
1528NGLDDSFKFWRAPSRubiquitination[1, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1593 AA 
Protein Sequence
MVLAGLIRKL GHQLAEIRER ALKSILCKIE HNLICYADLI QERQLFLHLL EWFNFPSVPM 60
KEEVLNLLSR LVKYPPAVQH LVDVGAVEFL SKLRSNVEPN LQAEIDGILD GLFLLPSEVP 120
ALSSASYQTN QTELSKNPEI LTGYFPQDKS NFQQMEVPPR PVVNQTVKCL KFSTFPWLPL 180
TTTDRHVLSS NESSLRSSNH TLIWNTCELL KDVIMQDFPA EIFLQRPKIV QSLLSLLKLA 240
FGDGKHRLAL QSVSCLQQLC MYLRNRLNFH RDPGFFSNKH DTVSQNSSLS YCHEARGTHH 300
SQNPSPGSSS PRPSVVGRTG QRPRGDGQDW DAASSSGSSS HAHVNSRISV HSPLDMGHID 360
LPELETEDTL ELQFQQLSLP QFCVSILESA VPLLRTGSRQ VIIRVLELLT EDMTLIGEAI 420
STDIWDDSSL FGIDMKEKLL LVLGALGETM CYHKSSISLE QPEVMLVHHR MAFISISLFA 480
VRLLQTLLPV EKASEFLSEP MSTALFLLSL DMPISLEYPN IHEAVVAYLE QLNSENYSIY 540
KRTAEAVYSI ECTCNFLSDI GKEGEKNLLE LVELADQALR SFSYHQHFPL IKEIISICSK 600
IWKSAQASPL LQGESQKVLL HMLSHPLPRV KAETYHCCLE ITKECLGVHN VTKPVSSLCN 660
GIHFLLHPKV LYEISVFGIQ EPESEVNTAA KAILLYLLQG RLMMTALTWN KFIESLCPVI 720
PILQGYADTE DPLGNCILLL SKASSDTEEM LPCTTRLKSM LRLLLVKKPS VRSLALKLLA 780
FHLTSEEGAD TKRPLIDARV LSRVTDLFIG KKPIELRLDD RRELVIKLET VEKVYEIFTS 840
DDVDLVLRKS AAEQLAVIMQ DIKMHAVVKK LCLIDKIIEY LNECVSQDGK VVECLVQPCL 900
TLLRKVLCGD PVMRVSLSQQ SSLLTVLFRV SLIFHEDCSV VTEVGALFCL LLFDEVSRMD 960
MWSVNPSNKP SLPSVFSLPV SVFRRYHLPV HVIGHHAVSP YSIVLPLSAD CLALKPVSDM 1020
LRIAWNLSWY HGSDNLLKQM NSETKTQEIL DALKLSTEDI LTLKITHMAS GLQDCLHSIV 1080
QAATHREVRA AVTRMSFYLL NDRLSLKGCP GPCGVTLKSL AWHTALNRFL QVLPACTEDE 1140
KLLIDIIHFL NKLIKEQRKN SSLELLNWIL ELLLRHSANP LLDLLVLTES QAREETDDIR 1200
TAVRQQLQKE LIALFDTLLL NFMEVTDRKC SELLYVFQTQ LALKLLQCLK VTDAPHFYGL 1260
PSLERTLRGM ANLTAFPGWS SHSPLTKPLD ICVKYLSGLL EVITSFYVER GGNAMSFMGK 1320
GVTKSTILCL LHLSHEMMAQ AGSLEWMSLW FLPLGSHSEE HIPTQQGLAW LIPLWVDRDP 1380
EVRFTSLGLG SALTTLETGC VALANSCQNI SGGLWGTVVN ILLDQSECSM VRREAAFILQ 1440
NLLVIPMPTE IIKDYTWQGP CVHDEDSGLS LIGKPALQAL LYHCHFYEHL NQMVKHCYLG 1500
RCMFDLNFSA FDRNSESNDL NGLDDSFKFW RAPSRTSQDR DPSSLSTSET TVAPSLGSTE 1560
FQPLVQSTTL LPEASHDQFV AQGNRHFGTN IQF 1593 
Gene Ontology
  
Interpro
 IPR016024; ARM-type_fold. 
Pfam
  
SMART
  
PROSITE
  
PRINTS