UniProt Accession

 PP2BB_HUMAN; P16298; P16299; Q5F2F9; Q8N1F0; Q8N3W4 

Genbank Protein ID

 M29551; M29550; AJ488506; AL353731; AL359074; AL359074; AL353731; CH471083; CH471083; BC028049 

Genbank Nucleotide ID

 AAA35706.1; AAA35705.1; CAD32694.1; CAI52487.1; CAI52487.1; CAI52473.1; CAI52473.1; EAW54497.1; EAW54498.1; AAH28049.1 

Protein Name

 Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform 

Protein Synonyms/Alias

 CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit beta isoform 

Gene Name

 PPP3CB 

Gene Synonyms/Alias

 CALNA2; CALNB; CNA2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
56	IPRVDVLKNHLVKEG	ubiquitination	[1, 2]
332	NNKAAVLKYENNVMN	ubiquitination	[1]
433	SESVLTLKGLTPTGM	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. 

Sequence Annotation

 REGION 2 310 Catalytic.
 REGION 256 262 Calcineurin B binding-site 1 (Potential).
 REGION 305 310 Calcineurin B binding-site 2 (Potential).
 REGION 401 423 Calmodulin-binding (Potential).
 REGION 474 496 Inhibitory domain.
 ACT_SITE 160 160 Proton donor (By similarity).
 METAL 99 99 Iron (By similarity).
 METAL 101 101 Iron (By similarity).
 METAL 127 127 Iron (By similarity).
 METAL 127 127 Zinc (By similarity).
 METAL 159 159 Zinc (By similarity).
 METAL 208 208 Zinc (By similarity).
 METAL 290 290 Zinc (By similarity).
 MOD_RES 2 2 N-acetylalanine.  

Keyword

 Acetylation; Alternative splicing; Calmodulin-binding; Complete proteome; Hydrolase; Iron; Metal-binding; Protein phosphatase; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 524 AA 

Protein Sequence

Gene Ontology

 GO:0005955; C:calcineurin complex; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0005509; F:calcium ion binding; IDA:UniProtKB.
 GO:0005516; F:calmodulin binding; IDA:UniProtKB.
 GO:0033192; F:calmodulin-dependent protein phosphatase activity; ISS:UniProtKB.
 GO:0008144; F:drug binding; IDA:UniProtKB.
 GO:0030346; F:protein phosphatase 2B binding; IDA:UniProtKB.
 GO:0048675; P:axon extension; TAS:UniProtKB.
 GO:0017156; P:calcium ion-dependent exocytosis; ISS:UniProtKB.
 GO:0035690; P:cellular response to drug; IDA:UniProtKB.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0007612; P:learning; TAS:UniProtKB.
 GO:0007613; P:memory; TAS:UniProtKB.
 GO:0001915; P:negative regulation of T cell mediated cytotoxicity; IEA:Compara.
 GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; ISS:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; NAS:UniProtKB.
 GO:0006470; P:protein dephosphorylation; ISS:UniProtKB.
 GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
 GO:0048167; P:regulation of synaptic plasticity; TAS:UniProtKB.
 GO:0034097; P:response to cytokine stimulus; IEA:Compara.
 GO:0007165; P:signal transduction; NAS:UniProtKB.
 GO:0035176; P:social behavior; IEP:UniProtKB.
 GO:0030217; P:T cell differentiation; IEA:Compara.
 GO:0043029; P:T cell homeostasis; IEA:Compara.
 GO:0042098; P:T cell proliferation; NAS:UniProtKB. 

Interpro

 IPR004843; Metallo_PEstase_dom.
 IPR006186; Ser/Thr-sp_prot-phosphatase. 

Pfam

 PF00149; Metallophos 

SMART

 SM00156; PP2Ac 

PROSITE

 PS00125; SER_THR_PHOSPHATASE 

PRINTS

 PR00114; STPHPHTASE.