| Tag | Content |
|---|
| CPLM ID | CPLM-024021 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sodium bicarbonate cotransporter 3 |
Protein Synonyms/Alias | Sodium bicarbonate cotransporter 2; Sodium bicarbonate cotransporter 2b; Bicarbonate transporter; Solute carrier family 4 member 7 |
Gene Name | SLC4A7 |
Gene Synonyms/Alias | BT; NBC2; NBC2B; NBC3; SBC2; SLC4A6 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 23 | EAVVDLGKTSSTVNT | ubiquitination | [1, 2] | | 31 | TSSTVNTKFEKEELE | ubiquitination | [1, 2] | | 34 | TVNTKFEKEELESHR | ubiquitination | [1] | | 130 | DGEEYEWKETARWLK | ubiquitination | [1] | | 137 | KETARWLKFEEDVED | ubiquitination | [1] | | 222 | RHHHQNEKRFTSRIP | ubiquitination | [1] | | 391 | PGNLDNSKSGEIKGN | ubiquitination | [1, 2] | | 477 | LLLGPAGKAPQYHEI | ubiquitination | [2] | | 503 | IFHDVAYKAKDRNDL | ubiquitination | [1] | | 539 | SIRIEPPKSVPSQEK | ubiquitination | [1] | | 546 | KSVPSQEKRKIPVFH | ubiquitination | [1, 2] | | 548 | VPSQEKRKIPVFHNG | ubiquitination | [1] | | 565 | PTLGETPKEAAHHAG | ubiquitination | [2] | | 590 | GGLILDIKRKAPFFL | ubiquitination | [1] | | 784 | ETLAQWKKDNITAHN | ubiquitination | [1] | | 947 | RKEHKLKKGAGYHLD | ubiquitination | [1] | | 1196 | PDKPVSVKISFEDEP | ubiquitination | [1, 2] | | 1206 | FEDEPRKKYVDAETS | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity. |
Sequence Annotation | REGION 1134 1136 CA2-binding.
MOTIF 1211 1214 PDZ-binding.
MOD_RES 233 233 Phosphoserine (By similarity).
MOD_RES 242 242 Phosphoserine.
MOD_RES 379 379 Phosphoserine (By similarity).
MOD_RES 403 403 Phosphoserine.
MOD_RES 407 407 Phosphoserine (By similarity).
MOD_RES 1167 1167 Phosphothreonine.
MOD_RES 1176 1176 Phosphoserine.
MOD_RES 1213 1213 Phosphoserine.
CARBOHYD 171 171 N-linked (GlcNAc...) (Potential).
CARBOHYD 269 269 N-linked (GlcNAc...) (Potential).
CARBOHYD 398 398 N-linked (GlcNAc...) (Potential).
CARBOHYD 406 406 N-linked (GlcNAc...) (Potential).
CARBOHYD 776 776 N-linked (GlcNAc...).
CARBOHYD 786 786 N-linked (GlcNAc...).
CARBOHYD 791 791 N-linked (GlcNAc...). |
Keyword | Alternative splicing; Cell membrane; Cell projection; Complete proteome; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1214 AA |
Protein Sequence | MERFRLEKKL PGPDEEAVVD LGKTSSTVNT KFEKEELESH RAVYIGVHVP FSKESRRRHR 60
HRGHKHHHRR RKDKESDKED GRESPSYDTP SQRVQFILGT EDDDEEHIPH DLFTEMDELC 120
YRDGEEYEWK ETARWLKFEE DVEDGGDRWS KPYVATLSLH SLFELRSCIL NGTVMLDMRA 180
STLDEIADMV LDNMIASGQL DESIRENVRE ALLKRHHHQN EKRFTSRIPL VRSFADIGKK 240
HSDPHLLERN GEGLSASRHS LRTGLSASNL SLRGESPLSL LLGHLLPSSR AGTPAGSRCT 300
TPVPTPQNSP PSSPSISRLT SRSSQESQRQ APELLVSPAS DDIPTVVIHP PEEDLEAALK 360
GEEQKNEENV DLTPGILASP QSAPGNLDNS KSGEIKGNGS GGSRENSTVD FSKVDMNFMR 420
KIPTGAEASN VLVGEVDFLE RPIIAFVRLA PAVLLTGLTE VPVPTRFLFL LLGPAGKAPQ 480
YHEIGRSIAT LMTDEIFHDV AYKAKDRNDL LSGIDEFLDQ VTVLPPGEWD PSIRIEPPKS 540
VPSQEKRKIP VFHNGSTPTL GETPKEAAHH AGPELQRTGR LFGGLILDIK RKAPFFLSDF 600
KDALSLQCLA SILFLYCACM SPVITFGGLL GEATEGRISA IESLFGASLT GIAYSLFAGQ 660
PLTILGSTGP VLVFEKILYK FCRDYQLSYL SLRTSIGLWT SFLCIVLVAT DASSLVCYIT 720
RFTEEAFAAL ICIIFIYEAL EKLFDLGETY AFNMHNNLDK LTSYSCVCTE PPNPSNETLA 780
QWKKDNITAH NISWRNLTVS ECKKLRGVFL GSACGHHGPY IPDVLFWCVI LFFTTFFLSS 840
FLKQFKTKRY FPTKVRSTIS DFAVFLTIVI MVTIDYLVGV PSPKLHVPEK FEPTHPERGW 900
IISPLGDNPW WTLLIAAIPA LLCTILIFMD QQITAVIINR KEHKLKKGAG YHLDLLMVGV 960
MLGVCSVMGL PWFVAATVLS ISHVNSLKVE SECSAPGEQP KFLGIREQRV TGLMIFILMG 1020
LSVFMTSVLK FIPMPVLYGV FLYMGVSSLK GIQLFDRIKL FGMPAKHQPD LIYLRYVPLW 1080
KVHIFTVIQL TCLVLLWVIK VSAAAVVFPM MVLALVFVRK LMDLCFTKRE LSWLDDLMPE 1140
SKKKKEDDKK KKEKEEAERM LQDDDDTVHL PFEGGSLLQI PVKALKYSPD KPVSVKISFE 1200
DEPRKKYVDA ETSL 1214 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell. GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; NAS:UniProtKB. GO:0005886; C:plasma membrane; TAS:Reactome. GO:0032420; C:stereocilium; IEA:UniProtKB-SubCell. GO:0005452; F:inorganic anion exchanger activity; IEA:InterPro. GO:0008510; F:sodium:bicarbonate symporter activity; NAS:UniProtKB. GO:0060117; P:auditory receptor cell development; IEA:Compara. GO:0021747; P:cochlear nucleus development; IEA:Compara. GO:0061299; P:retina vasculature morphogenesis in camera-type eye; IEA:Compara. GO:0046666; P:retinal cell programmed cell death; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |