UniProt Accession

 MOC2B_MOUSE; Q9Z223; Q8C5E5; Q8R1M7; Q9DCK1 

Genbank Protein ID

 AF091872; AK002719; AK010112; AK078782; CH466568; CH466568; BC024371 

Genbank Nucleotide ID

 AAD14601.1; BAB22306.1; BAB26707.2; BAC37393.1; EDL18371.1; EDL18372.1; AAH24371.1 

Protein Name

 Molybdopterin synthase catalytic subunit 

Protein Synonyms/Alias

 Molybdenum cofactor synthesis protein 2 large subunit; Molybdenum cofactor synthesis protein 2B; MOCS2B 

Gene Name

 Mocs2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
42	DVDDVQEKPKDIIQF	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group (By similarity). 

Sequence Annotation

 REGION 143 144 Substrate binding (By similarity).
 REGION 166 168 Substrate binding (By similarity).
 BINDING 159 159 Substrate (By similarity).
 MOD_RES 20 20 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Molybdenum cofactor biosynthesis; Phosphoprotein; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 189 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0019008; C:molybdopterin synthase complex; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0030366; F:Mo-molybdopterin synthase activity; ISS:UniProtKB.
 GO:0016740; F:transferase activity; IEA:UniProtKB-KW. 

Interpro

 IPR003448; Mopterin_biosynth_MoaE. 

Pfam

 PF02391; MoaE 

SMART

  

PROSITE

  

PRINTS