CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040140
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ribosomal protein S6 kinase 
Protein Synonyms/Alias
  
Gene Name
 Rps6ka1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
563ICDFGFAKQLRAENGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 736 AA 
Protein Sequence
MAWISYMPCC PGRAPRLQRG PHTTHHTPHL PALSLCQDEA ILKEISITHH VKAGSEKADP 60
SQFELLKVLG QGSFGKVFLV RKVTRPDSGH LYAMKVLKKA TLKVRDRVRT KMERDILADV 120
NHPFVVKLHY AFQTEGKLYL ILDFLRGGDL FTRLSKEVMF TEEDVKFYLA ELALGLDHLH 180
SLGIIYRDLK PENILLDEEG HIKLTDFGLS KEAIDHEKKA YSFCGTVEYM APEVVNRQGH 240
THSADWWSYG VLMFEMLTGS LPFQGKDRKE TMTLILKAKL GMPQFLSTEA QSLLRALFKR 300
NPANRLGSGP DGAEEIKRHI FYSTIDWNKL YRREIKPPFK PAVAQPDDTF YFDTEFTSRT 360
PRDSPGIPPS AGAHQLFRGF SFVATGLMED DGKPRTTQAP LHSVVQQLHG KNLVFSDGYV 420
VKETIGVGSY SVCKRCVHKA TNMEYAVKVI DKSKRDPSEE IEILLRYGQH PNIITLKDVY 480
DDGKHVYLVT ELMRGGELLD KILRQKFFSE REASFVLHTI SKTVEYLHSQ GVVHRDLKPS 540
NILYVDESGN PECLRICDFG FAKQLRAENG LLMTPCYTAN FVAPEVLKRQ GYDEGCDIWS 600
LGILLYTMLA GYTPFANGPS DTPEEILTRI GSGKFTLSGG NWNTVSETAK DLVSKMLHVD 660
PHQRLTAKQV LQHPWITQKD KLPQSQLSHQ DLQLVKGAMA ATYSALNSSK PTPQLKPIES 720
SILAQRRVRK LPSTTL 736 
Gene Ontology
 GO:0005819; C:spindle; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro. 
Interpro
 IPR000961; AGC-kinase_C.
 IPR011009; Kinase-like_dom.
 IPR017892; Pkinase_C.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR016239; Ribosomal_S6_kinase_II.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase
 PF00433; Pkinase_C 
SMART
 SM00133; S_TK_X
 SM00220; S_TKc 
PROSITE
 PS51285; AGC_KINASE_CTER
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS