CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018370
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 THAP domain-containing protein 4 
Protein Synonyms/Alias
  
Gene Name
 THAP4 
Gene Synonyms/Alias
 CGI-36; PP238 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
356CFSSRQNKSQVCCLRubiquitination[1, 2]
374EKKNGELKSLRQRVSubiquitination[1]
532IARISFAKEPHVEQIubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
 ZN_FING 1 85 THAP-type.
 MOTIF 235 238 HCFC1-binding motif (HBM) (By
 METAL 567 567 Iron (heme axial ligand).
 MOD_RES 163 163 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; DNA-binding; Heme; Iron; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 577 AA 
Protein Sequence
MVICCAAVNC SNRQGKGEKR AVSFHRFPLK DSKRLIQWLK AVQRDNWTPT KYSFLCSEHF 60
TKDSFSKRLE DQHRLLKPTA VPSIFHLTEK KRGAGGHGRT RRKDASKATG GVRGHSSAAT 120
SRGAAGWSPS SSGNPMAKPE SRRLKQAALQ GEATPRAAQE AASQEQAQQA LERTPGDGLA 180
TMVAGSQGKA EASATDAGDE SATSSIEGGV TDKSGISMDD FTPPGSGACK FIGSLHSYSF 240
SSKHTRERPS VPREPIDRKR LKKDVEPSCS GSSLGPDKGL AQSPPSSSLT ATPQKPSQSP 300
SAPPADVTPK PATEAVQSEH SDASPMSINE VILSASGACK LIDSLHSYCF SSRQNKSQVC 360
CLREQVEKKN GELKSLRQRV SRSDSQVRKL QEKLDELRRV SVPYPSSLLS PSREPPKMNP 420
VVEPLSWMLG TWLSDPPGAG TYPTLQPFQY LEEVHISHVG QPMLNFSFNS FHPDTRKPMH 480
RECGFIRLKP DTNKVAFVSA QNTGVVEVEE GEVNGQELCI ASHSIARISF AKEPHVEQIT 540
RKFRLNSEGK LEQTVSMATT TQPMTQHLHV TYKKVTP 577 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 
Interpro
 IPR011038; Calycin-like.
 IPR014878; DUF1794.
 IPR006612; Znf_C2CH. 
Pfam
 PF08768; DUF1794
 PF05485; THAP 
SMART
 SM00692; DM3
 SM00980; THAP 
PROSITE
 PS50950; ZF_THAP 
PRINTS