CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022542
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Armadillo repeat-containing X-linked protein 1 
Protein Synonyms/Alias
 ARM protein lost in epithelial cancers on chromosome X 1; Protein ALEX1 
Gene Name
 ARMCX1 
Gene Synonyms/Alias
 ALEX1; AD032 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
56EIGVETVKGAKTNAGubiquitination[1]
266KDPIIREKTYNALNNubiquitination[2]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
 REPEAT 195 235 ARM 1.
 REPEAT 237 276 ARM 2.
 REPEAT 358 398 ARM 3.  
Keyword
 Complete proteome; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 453 AA 
Protein Sequence
MGRTREAGCV AAGVVIGAGA CYCVYRLAWG RDENEKIWDE DEESTDTSEI GVETVKGAKT 60
NAGAGSGAKL QGDSEVKPEV SLGLEDCPGV KEKAHSGSHS GGGLEAKAKA LFNTLKEQAS 120
AKAGKGARVG TISGNRTLAP SLPCPGGRGG GCHPTRSGSR AGGRASGKSK GKARSKSTRA 180
PATTWPVRRG KFNFPYKIDD ILSAPDLQKV LNILERTNDP FIQEVALVTL GNNAAYSFNQ 240
NAIRELGGVP IIAKLIKTKD PIIREKTYNA LNNLSVNAEN QGKIKTYISQ VCDDTMVCRL 300
DSAVQMAGLR LLTNMTVTNH YQHLLSYSFP DFFALLFLGN HFTKIQIMKL IINFTENPAM 360
TRELVSCKVP SELISLFNKE WDREILLNIL TLFENINDNI KNEGLASSRK EFSRSSLFFL 420
FKESGVCVKK IKALANHNDL VVKVKVLKVL TKL 453 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 
Interpro
 IPR011989; ARM-like.
 IPR006911; ARM-rpt_dom.
 IPR016024; ARM-type_fold.
 IPR000225; Armadillo. 
Pfam
 PF04826; Arm_2 
SMART
  
PROSITE
 PS50176; ARM_REPEAT 
PRINTS