CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023846
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Insulin receptor substrate 2 
Protein Synonyms/Alias
 IRS-2 
Gene Name
 IRS2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
295LEAMKALKELFEFRPubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 May mediate the control of various cellular processes by insulin. 
Sequence Annotation
 DOMAIN 16 144 PH.
 DOMAIN 194 298 IRS-type PTB.
 MOTIF 540 543 YXXM motif 1.
 MOTIF 598 601 YXXM motif 2.
 MOTIF 653 656 YXXM motif 3.
 MOTIF 675 678 YXXM motif 4.
 MOTIF 742 745 YXXM motif 5.
 MOTIF 823 826 YXXM motif 6.
 MOTIF 1072 1075 YXXM motif 7.
 MOD_RES 306 306 Phosphoserine.
 MOD_RES 346 346 Phosphoserine.
 MOD_RES 350 350 Phosphothreonine.
 MOD_RES 365 365 Phosphoserine.
 MOD_RES 384 384 Phosphoserine.
 MOD_RES 388 388 Phosphoserine.
 MOD_RES 391 391 Phosphoserine.
 MOD_RES 523 523 Phosphoserine.
 MOD_RES 527 527 Phosphothreonine.
 MOD_RES 540 540 Phosphotyrosine; by INSR (By similarity).
 MOD_RES 560 560 Phosphoserine.
 MOD_RES 577 577 Phosphoserine.
 MOD_RES 579 579 Phosphothreonine.
 MOD_RES 580 580 Phosphothreonine.
 MOD_RES 594 594 Phosphoserine.
 MOD_RES 608 608 Phosphoserine.
 MOD_RES 620 620 Phosphoserine.
 MOD_RES 653 653 Phosphotyrosine; by INSR.
 MOD_RES 675 675 Phosphotyrosine; by INSR.
 MOD_RES 679 679 Phosphoserine.
 MOD_RES 735 735 Phosphoserine.
 MOD_RES 736 736 Phosphoserine.
 MOD_RES 770 770 Phosphoserine.
 MOD_RES 779 779 Phosphothreonine.
 MOD_RES 828 828 Phosphoserine.
 MOD_RES 915 915 Phosphoserine.
 MOD_RES 919 919 Phosphotyrosine; by INSR (By similarity).
 MOD_RES 973 973 Phosphoserine.
 MOD_RES 978 978 Phosphotyrosine; by INSR (By similarity).
 MOD_RES 1100 1100 Phosphoserine.
 MOD_RES 1159 1159 Phosphothreonine.
 MOD_RES 1162 1162 Phosphoserine.
 MOD_RES 1174 1174 Phosphoserine.
 MOD_RES 1176 1176 Phosphoserine.
 MOD_RES 1203 1203 Phosphoserine.
 MOD_RES 1253 1253 Phosphotyrosine; by INSR (By similarity).  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Phosphoprotein; Polymorphism; Reference proteome; Transducer. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1338 AA 
Protein Sequence
MASPPRHGPP GPASGDGPNL NNNNNNNNHS VRKCGYLRKQ KHGHKRFFVL RGPGAGGDEA 60
TAGGGSAPQP PRLEYYESEK KWRSKAGAPK RVIALDCCLN INKRADAKHK YLIALYTKDE 120
YFAVAAENEQ EQEGWYRALT DLVSEGRAAA GDAPPAAAPA ASCSASLPGA LGGSAGAAGA 180
EDSYGLVAPA TAAYREVWQV NLKPKGLGQS KNLTGVYRLC LSARTIGFVK LNCEQPSVTL 240
QLMNIRRCGH SDSFFFIEVG RSAVTGPGEL WMQADDSVVA QNIHETILEA MKALKELFEF 300
RPRSKSQSSG SSATHPISVP GARRHHHLVN LPPSQTGLVR RSRTDSLAAT PPAAKCSSCR 360
VRTASEGDGG AAAGAAAAGA RPVSVAGSPL SPGPVRAPLS RSHTLSGGCG GRGSKVALLP 420
AGGALQHSRS MSMPVAHSPP AATSPGSLSS SSGHGSGSYP PPPGPHPPLP HPLHHGPGQR 480
PSSGSASASG SPSDPGFMSL DEYGSSPGDL RAFCSHRSNT PESIAETPPA RDGGGGGEFY 540
GYMTMDRPLS HCGRSYRRVS GDAAQDLDRG LRKRTYSLTT PARQRPVPQP SSASLDEYTL 600
MRATFSGSAG RLCPSCPASS PKVAYHPYPE DYGDIEIGSH RSSSSNLGAD DGYMPMTPGA 660
ALAGSGSGSC RSDDYMPMSP ASVSAPKQIL QPRAAAAAAA AVPSAGPAGP APTSAAGRTF 720
PASGGGYKAS SPAESSPEDS GYMRMWCGSK LSMEHADGKL LPNGDYLNVS PSDAVTTGTP 780
PDFFSAALHP GGEPLRGVPG CCYSSLPRSY KAPYTCGGDS DQYVLMSSPV GRILEEERLE 840
PQATPGPSQA ASAFGAGPTQ PPHPVVPSPV RPSGGRPEGF LGQRGRAVRP TRLSLEGLPS 900
LPSMHEYPLP PEPKSPGEYI NIDFGEPGAR LSPPAPPLLA SAASSSSLLS ASSPASSLGS 960
GTPGTSSDSR QRSPLSDYMN LDFSSPKSPK PGAPSGHPVG SLDGLLSPEA SSPYPPLPPR 1020
PSASPSSSLQ PPPPPPAPGE LYRLPPASAV ATAQGPGAAS SLSSDTGDNG DYTEMAFGVA 1080
ATPPQPIAAP PKPEAARVAS PTSGVKRLSL MEQVSGVEAF LQASQPPDPH RGAKVIRADP 1140
QGGRRRHSSE TFSSTTTVTP VSPSFAHNPK RHNSASVENV SLRKSSEGGV GVGPGGGDEP 1200
PTSPRQLQPA PPLAPQGRPW TPGQPGGLVG CPGSGGSPMR RETSAGFQNG LNYIAIDVRE 1260
EPGLPPQPQP PPPPLPQPGD KSSWGRTRSL GGLISAVGVG STGGGCGGPG PGALPPANTY 1320
ASIDFLSHHL KEATIVKE 1338 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0004871; F:signal transducer activity; TAS:ProtInc.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.
 GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.
 GO:0006006; P:glucose metabolic process; TAS:ProtInc.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0008286; P:insulin receptor signaling pathway; ISS:BHF-UCL.
 GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; TAS:Reactome.
 GO:0055088; P:lipid homeostasis; TAS:BHF-UCL.
 GO:0030879; P:mammary gland development; IEA:Compara.
 GO:0002903; P:negative regulation of B cell apoptotic process; ISS:BHF-UCL.
 GO:0033673; P:negative regulation of kinase activity; ISS:BHF-UCL.
 GO:0010748; P:negative regulation of plasma membrane long-chain fatty acid transport; IMP:BHF-UCL.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome.
 GO:0030890; P:positive regulation of B cell proliferation; ISS:BHF-UCL.
 GO:0030335; P:positive regulation of cell migration; IEA:Compara.
 GO:0032000; P:positive regulation of fatty acid beta-oxidation; IMP:BHF-UCL.
 GO:0046326; P:positive regulation of glucose import; IMP:BHF-UCL.
 GO:0045725; P:positive regulation of glycogen biosynthetic process; IMP:BHF-UCL.
 GO:0032024; P:positive regulation of insulin secretion; ISS:BHF-UCL.
 GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Compara.
 GO:0009749; P:response to glucose stimulus; ISS:BHF-UCL. 
Interpro
 IPR002404; Insln_rcpt_S1.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF02174; IRS
 PF00169; PH 
SMART
 SM00233; PH
 SM00310; PTBI 
PROSITE
 PS51064; IRS_PTB
 PS50003; PH_DOMAIN 
PRINTS
 PR00628; INSULINRSI.