| Tag | Content |
|---|
| CPLM ID | CPLM-018940 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial |
Protein Synonyms/Alias | Flavoprotein subunit of complex II; FP; Succinyl coenzyme A synthetase flavoprotein subunit |
Gene Name | SdhA |
Gene Synonyms/Alias | Scs-fp; CG17246 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 176 | AFGGQSLKFGKGGQA | acetylation | [1] | | 332 | ERYAPVAKDLASRDV | acetylation | [1] | | 423 | GQVITIDKDGKDVIV | acetylation | [1] | | 542 | NKMKEIYKQFKDIKV | acetylation | [1] | | 606 | EDEYDFSKPLDGQQK | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Maintaining electron transport chain function is required to prevent neurodegenerative changes seen in both early- and late-onset disorders. |
Sequence Annotation | NP_BIND 65 70 FAD (By similarity).
NP_BIND 88 103 FAD (By similarity).
NP_BIND 454 455 FAD (By similarity).
ACT_SITE 337 337 Proton acceptor (By similarity).
BINDING 272 272 FAD (By similarity).
BINDING 293 293 Substrate (By similarity).
BINDING 305 305 Substrate (By similarity).
BINDING 404 404 Substrate (By similarity).
BINDING 438 438 FAD (By similarity).
BINDING 449 449 Substrate (By similarity).
MOD_RES 96 96 Tele-8alpha-FAD histidine (By |
Keyword | Complete proteome; Electron transport; FAD; Flavoprotein; Membrane; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Reference proteome; Transit peptide; Transport; Tricarboxylic acid cycle. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 661 AA |
Protein Sequence | MSGIMRVPSI LAKNAVASMQ RAAAVGVQRS YHITHGRQQA SAANPDKISK QYPVVDHAYD 60
AIVVGAGGAG LRAAFGLVAE GFRTAVITKL FPTRSHTIAA QGGINAALGN MEEDDWKWHM 120
YDTVKGSDWL GDQDAIHYMT REAPKAVIEL ENYGMPFSRT QDGKIYQRAF GGQSLKFGKG 180
GQAHRCCAVA DRTGHSLLHT LYGQSLSYDC NYFVEYFALD LIFEDGECRG VLALNLEDGT 240
LHRFRAKNTV IATGGYGRAF FSCTSAHTCT GDGTAMVARQ GLPSQDLEFV QFHPTGIYGA 300
GCLITEGCRG EGGYLINGNG ERFMERYAPV AKDLASRDVV SRSMTIEIME GRGAGPEKDH 360
VYLQLHHLPP KQLAERLPGI SETAMIFAGV DVTREPIPVL PTVHYNMGGV PTNYRGQVIT 420
IDKDGKDVIV PGLYAAGEAA SSSVHGANRL GANSLLDLVV FGRACAKTIA ELNKPGAPAP 480
TLKENAGEAS VANLDKLRHA NGQITTADLR LKMQKTMQHH AAVFRDGPIL QDGVNKMKEI 540
YKQFKDIKVV DRSLIWNSDL VETLELQNLL ANAQMTIVSA EARKESRGAH AREDFKVRED 600
EYDFSKPLDG QQKKPMDQHW RKHTLSWVCN DNGDITLDYR NVIDTTLDNE VSTVPPAIRS 660
Y 661 |
Gene Ontology | GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. GO:0005739; C:mitochondrion; IDA:FlyBase. GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro. GO:0008177; F:succinate dehydrogenase (ubiquinone) activity; IEA:EC. GO:0022900; P:electron transport chain; IMP:UniProtKB. GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |