CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020279
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 FUN14 domain-containing protein 2 
Protein Synonyms/Alias
 Cervical cancer proto-oncogene 3 protein; HCC-3; Hepatitis C virus core-binding protein 6 
Gene Name
 FUNDC2 
Gene Synonyms/Alias
 HCBP6; DC44; HCC3; PD03104 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
61LDLAEFAKKQPWWRKubiquitination[1, 2]
62DLAEFAKKQPWWRKLubiquitination[3]
68KKQPWWRKLFGQESGubiquitination[4]
150KEQLKIRKSNQIPTEubiquitination[1, 3, 5, 6]
161IPTEVRSKAEEVVSFubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
 MOD_RES 151 151 Phosphoserine.  
Keyword
 Complete proteome; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 189 AA 
Protein Sequence
METSAPRAGS QVVATTARHS AAYRADPLRV SSRDKLTEMA ASSQGNFEGN FESLDLAEFA 60
KKQPWWRKLF GQESGPSAEK YSVATQLFIG GVTGWCTGFI FQKVGKLAAT AVGGGFFLLQ 120
LANHTGYIKV DWQRVEKDMK KAKEQLKIRK SNQIPTEVRS KAEEVVSFVK KNVLVTGGFF 180
GGFLLGMAS 189 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:LIFEdb. 
Interpro
 IPR007014; FUN14. 
Pfam
 PF04930; FUN14 
SMART
  
PROSITE
  
PRINTS