UniProt Accession

 PGK1_PANTR; A5A6K4 

Genbank Protein ID

 AB222132 

Genbank Nucleotide ID

 BAF62377.1 

Protein Name

 Phosphoglycerate kinase 1 

Protein Synonyms/Alias

  

Gene Name

 PGK1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Pan troglodytes (Chimpanzee) 

NCBI Taxa ID

 9598 

Lysine Modification

Position	Peptide	Type	References
6	**MSLSNKLTLDKLD	ubiquitination	[1]
11	SNKLTLDKLDVKGKR	ubiquitination	[1, 2]
30	VDFNVPMKNNQITNN	ubiquitination	[1, 2]
48	KAAVPSIKFCLDNGA	ubiquitination	[1, 2]
75	DGVPMPDKYSLEPVA	ubiquitination	[2]
86	EPVAVELKSLLGKDV	ubiquitination	[1, 2]
91	ELKSLLGKDVLFLKD	ubiquitination	[1, 2]
97	GKDVLFLKDCVGPEV	ubiquitination	[2]
146	KVKAEPAKIEAFRAS	ubiquitination	[2]
156	AFRASLSKLGDVYVN	ubiquitination	[1, 2]
184	VGVNLPQKAGGFLMK	ubiquitination	[2]
192	AGGFLMKKELNYFAK	ubiquitination	[2]
199	KELNYFAKALESPER	ubiquitination	[2]
216	LAILGGAKVADKIQL	ubiquitination	[1, 2]
220	GGAKVADKIQLINNM	ubiquitination	[1, 2]
264	LFDEEGAKIVKDLMS	ubiquitination	[2]
267	EEGAKIVKDLMSKAE	ubiquitination	[1, 2]
291	VDFVTADKFDENAKT	ubiquitination	[1, 2]
361	ALMDEVVKATSRGCI	ubiquitination	[1, 2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

 NP_BIND 373 376 ATP (By similarity).
 REGION 24 26 Substrate binding (By similarity).
 REGION 63 66 Substrate binding (By similarity).
 BINDING 39 39 Substrate (By similarity).
 BINDING 123 123 Substrate (By similarity).
 BINDING 171 171 Substrate (By similarity).
 BINDING 220 220 ATP (By similarity).
 BINDING 313 313 ATP; via carbonyl oxygen (By similarity).
 BINDING 344 344 ATP (By similarity).
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 11 11 N6-acetyllysine (By similarity).
 MOD_RES 48 48 N6-acetyllysine (By similarity).
 MOD_RES 75 75 N6-acetyllysine (By similarity).
 MOD_RES 76 76 Phosphotyrosine (By similarity).
 MOD_RES 86 86 N6-acetyllysine (By similarity).
 MOD_RES 97 97 N6-acetyllysine (By similarity).
 MOD_RES 131 131 N6-acetyllysine; alternate (By
 MOD_RES 131 131 N6-malonyllysine; alternate (By
 MOD_RES 146 146 N6-acetyllysine (By similarity).
 MOD_RES 196 196 Phosphotyrosine (By similarity).
 MOD_RES 199 199 N6-acetyllysine (By similarity).
 MOD_RES 203 203 Phosphoserine (By similarity).
 MOD_RES 267 267 N6-acetyllysine (By similarity).
 MOD_RES 291 291 N6-acetyllysine (By similarity).
 MOD_RES 390 390 Phosphoserine (By similarity).  

Keyword

 Acetylation; ATP-binding; Complete proteome; Cytoplasm; Glycolysis; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 417 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004618; F:phosphoglycerate kinase activity; IEA:EC.
 GO:0006096; P:glycolysis; IEA:UniProtKB-UniPathway. 

Interpro

 IPR001576; Phosphoglycerate_kinase.
 IPR015901; Phosphoglycerate_kinase_C.
 IPR015911; Phosphoglycerate_kinase_CS.
 IPR015824; Phosphoglycerate_kinase_N. 

Pfam

 PF00162; PGK 

SMART

  

PROSITE

 PS00111; PGLYCERATE_KINASE 

PRINTS

 PR00477; PHGLYCKINASE.