| Tag | Content |
|---|
| CPLM ID | CPLM-019411 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | TNFAIP3-interacting protein 3 |
Protein Synonyms/Alias | A20-binding inhibitor of NF-kappa-B activation 3; ABIN-3; Listeria-induced gene protein |
Gene Name | TNIP3 |
Gene Synonyms/Alias | ABIN3; LIND |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 39 | LMNSLEQKIRCLEKQ | methylation | [1] |
|
Reference | [1] Large-scale global identification of protein lysine methylation in vivo. Cao XJ, Arnaudo AM, Garcia BA. Epigenetics. 2013 May 1;8(5):477-85. [ PMID: 23644510] |
Functional Description | Binds to zinc finger protein TNFAIP3 and inhibits NF- kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13- acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding. |
Sequence Annotation | REGION 190 248 Ubiquitin-binding domain (UBD). |
Keyword | Alternative splicing; Coiled coil; Complete proteome; Inflammatory response; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 325 AA |
Protein Sequence | MAHFVQGTSR MIAAESSTEH KECAEPSTRK NLMNSLEQKI RCLEKQRKEL LEVNQQWDQQ 60
FRSMKELYER KVAELKTKLD AAERFLSTRE KDPHQRQRKD DRQREDDRQR DLTRDRLQRE 120
EKEKERLNEE LHELKEENKL LKGKNTLANK EKEHYECEIK RLNKALQDAL NIKCSFSEDC 180
LRKSRVEFCH EEMRTEMEVL KQQVQIYEED FKKERSDRER LNQEKEELQQ INETSQSQLN 240
RLNSQIKACQ MEKEKLEKQL KQMYCPPCNC GLVFHLQDPW VPTGPGAVQK QREHPPDYQW 300
YALDQLPPDV QHKANGLSSV KKVHP 325 |
Gene Ontology | GO:0031593; F:polyubiquitin binding; IDA:UniProtKB. GO:0071222; P:cellular response to lipopolysaccharide; IDA:UniProtKB. GO:0006954; P:inflammatory response; IEA:UniProtKB-KW. GO:0002756; P:MyD88-independent toll-like receptor signaling pathway; IDA:UniProtKB. GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB cascade; IDA:UniProtKB. GO:0034142; P:toll-like receptor 4 signaling pathway; IDA:UniProtKB. |
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