UniProt Accession

 WIBG_HUMAN; Q9BRP8; B6ZDM5; Q8IXJ8; Q8N8E7 

Genbank Protein ID

 AJ459406; AK096922; AC023055; AC025162; BC006135; BC014976 

Genbank Nucleotide ID

 CAD30677.1; BAC04897.1; AAH06135.1; AAH14976.1 

Protein Name

 Partner of Y14 and mago 

Protein Synonyms/Alias

 Protein wibg homolog 

Gene Name

 WIBG 

Gene Synonyms/Alias

 PYM 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
51	VYENKYVKFFKSKPE	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post- transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC. 

Sequence Annotation

 REGION 1 33 Required for interaction with MAGOH and
 REGION 152 204 eIF2A-like.
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 6 6 Phosphoserine.
 MOD_RES 64 64 Phosphoserine.
 MOD_RES 72 72 Phosphothreonine.  

Keyword

 Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Nonsense-mediated mRNA decay; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; RNA-binding; Translation regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 204 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0035145; C:exon-exon junction complex; IDA:UniProtKB.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0043022; F:ribosome binding; IDA:UniProtKB.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IDA:UniProtKB.
 GO:0045727; P:positive regulation of translation; IDA:UniProtKB. 

Interpro

 IPR015362; EJC_Pym. 

Pfam

 PF09282; Mago-bind 

SMART

  

PROSITE

  

PRINTS