UniProt Accession

 C1QR1_MOUSE; O89103; A2AVY5; Q3U2X0 

Genbank Protein ID

 AF074856; AF081789; AF099939; AF099938; AK079060; AK155060; AL935149 

Genbank Nucleotide ID

 AAC63274.1; AAC62649.1; AAD47906.1; AAD47906.1; BAC37518.1; BAE33020.1; CAM26726.1 

Protein Name

 Complement component C1q receptor 

Protein Synonyms/Alias

 C1q/MBL/SPA receptor; C1qR(p); C1qRp; Cell surface antigen AA4; Complement component 1 q subcomponent receptor 1; Lymphocyte antigen 68; Ly-68; CD93 

Gene Name

 Cd93 

Gene Synonyms/Alias

 Aa4; C1qr1; C1qrp; Ly68 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
612	KEEIKEKKPQNAADS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion. Marker for early multipotent hematopoietic precursor cells. May play a role in cell-cell interactions during hematopoietic and vascular development. 

Sequence Annotation

 DOMAIN 31 173 C-type lectin.
 DOMAIN 257 298 EGF-like 1.
 DOMAIN 299 341 EGF-like 2.
 DOMAIN 342 381 EGF-like 3; calcium-binding (Potential).
 DOMAIN 382 423 EGF-like 4; calcium-binding (Potential).
 DOMAIN 424 465 EGF-like 5; calcium-binding (Potential).
 MOD_RES 636 636 Phosphotyrosine.
 CARBOHYD 102 102 N-linked (GlcNAc...) (Potential).
 CARBOHYD 322 322 N-linked (GlcNAc...) (Potential).
 DISULFID 140 164 By similarity.
 DISULFID 261 272 By similarity.
 DISULFID 268 282 By similarity.
 DISULFID 284 297 By similarity.
 DISULFID 303 314 By similarity.
 DISULFID 308 325 By similarity.
 DISULFID 327 340 By similarity.
 DISULFID 346 355 By similarity.
 DISULFID 351 364 By similarity.
 DISULFID 366 380 By similarity.
 DISULFID 386 397 By similarity.
 DISULFID 393 406 By similarity.
 DISULFID 408 422 By similarity.
 DISULFID 428 440 By similarity.
 DISULFID 436 449 By similarity.
 DISULFID 451 464 By similarity.  

Keyword

 Cell adhesion; Complete proteome; Disulfide bond; EGF-like domain; Glycoprotein; Lectin; Membrane; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 644 AA 

Protein Sequence

Gene Ontology

 GO:0009986; C:cell surface; IDA:MGI.
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0016337; P:cell-cell adhesion; ISS:UniProtKB. 

Interpro

 IPR001304; C-type_lectin.
 IPR016186; C-type_lectin-like.
 IPR016187; C-type_lectin_fold.
 IPR016316; CD93/CD141.
 IPR026823; cEGF.
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR018097; EGF_Ca-bd_CS. 

Pfam

 PF12662; cEGF
 PF00059; Lectin_C 

SMART

 SM00034; CLECT
 SM00181; EGF
 SM00179; EGF_CA 

PROSITE

 PS00010; ASX_HYDROXYL
 PS00615; C_TYPE_LECTIN_1
 PS50041; C_TYPE_LECTIN_2
 PS01186; EGF_2
 PS50026; EGF_3
 PS01187; EGF_CA 

PRINTS