Tag | Content |
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CPLM ID | CPLM-017471 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Chondroitin sulfate N-acetylgalactosaminyltransferase 2 |
Protein Synonyms/Alias | Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 2; Beta4GalNAcT-2; GalNAcT-2 |
Gene Name | CSGALNACT2 |
Gene Synonyms/Alias | CHGN2; GALNACT2; PRO0082 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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92 | ELQEMSEKMRSLQER | ubiquitination | [1] |
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Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. |
Sequence Annotation | METAL 369 369 Divalent metal cation (Potential). METAL 486 486 Divalent metal cation (Potential). CARBOHYD 41 41 N-linked (GlcNAc...) (Potential). CARBOHYD 333 333 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Coiled coil; Complete proteome; Glycoprotein; Golgi apparatus; Membrane; Metal-binding; Polymorphism; Reference proteome; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 542 AA |
Protein Sequence | MPRRGLILHT RTHWLLLGLA LLCSLVLFMY LLECAPQTDG NASLPGVVGE NYGKEYYQAL 60 LQEQEEHYQT RATSLKRQIA QLKQELQEMS EKMRSLQERR NVGANGIGYQ SNKEQAPSDL 120 LEFLHSQIDK AEVSIGAKLP SEYGVIPFES FTLMKVFQLE MGLTRHPEEK PVRKDKRDEL 180 VEVIEAGLEV INNPDEDDEQ EDEEGPLGEK LIFNENDFVE GYYRTERDKG TQYELFFKKA 240 DLTEYRHVTL FRPFGPLMKV KSEMIDITRS IINIIVPLAE RTEAFVQFMQ NFRDVCIHQD 300 KKIHLTVVYF GKEGLSKVKS ILESVTSESN FHNYTLVSLN EEFNRGRGLN VGARAWDKGE 360 VLMFFCDVDI YFSAEFLNSC RLNAEPGKKV FYPVVFSLYN PAIVYANQEV PPPVEQQLVH 420 KKDSGFWRDF GFGMTCQYRS DFLTIGGFDM EVKGWGGEDV HLYRKYLHGD LIVIRTPVPG 480 LFHLWHEKRC ADELTPEQYR MCIQSKAMNE ASHSHLGMLV FREEIETHLH KQAYRTNSEA 540 VG 542 |
Gene Ontology | GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell. GO:0030173; C:integral to Golgi membrane; NAS:UniProtKB. GO:0008376; F:acetylgalactosaminyltransferase activity; IDA:UniProtKB. GO:0047237; F:glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity; IEA:EC. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0030206; P:chondroitin sulfate biosynthetic process; TAS:Reactome. GO:0050653; P:chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; TAS:UniProtKB. GO:0050652; P:dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; TAS:UniProtKB. |
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